7UOT

Native Lassa glycoprotein in complex with neutralizing antibodies 8.9F and 37.2D

Summary for 7UOT

• Entry DOI: 10.2210/pdb7uot/pdb
• EMDB information: 26653
• Descriptor: Glycoprotein G1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• Functional Keywords: lassa virus, neutralizing antibody, n-linked glycans complex, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Lassa virus; More
• Total number of polymer chains: 14
• Total formula weight: 292032.54

Authors

Li, H.,Saphire, E.O. (deposition date: 2022-04-13, release date: 2022-11-02)

• Primary citation: Li, H.,Buck, T.,Zandonatti, M.,Yin, J.,Moon-Walker, A.,Fang, J.,Koval, A.,Heinrich, M.L.,Rowland, M.M.,Diaz Avalos, R.,Schendel, S.L.,Parekh, D.,Zyla, D.,Enriquez, A.,Harkins, S.,Sullivan, B.,Smith, V.,Chukwudozie, O.,Watanabe, R.,Robinson, J.E.,Garry, R.F.,Branco, L.M.,Hastie, K.M.,Saphire, E.O.; A cocktail of protective antibodies subverts the dense glycan shield of Lassa virus.; Sci Transl Med, 14:eabq0991-eabq0991, 2022; PubMed: 36288283; DOI: 10.1126/scitranslmed.abq0991

Experimental method

ELECTRON MICROSCOPY (2.77 Å)