PDB: 915 件ウェブページステータス検索Chemie searchBIRD

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8HIX	Cryo-EM structure of GPR21_m5_Gs 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-03-15 最終更新日 2023-03-22 実験手法 ELECTRON MICROSCOPY (3.12 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
8HJ5	Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... 著者 Gan, B, Yu, L.Y, Ren, R.B. 登録日 2022-11-22 公開日 2023-05-31 最終更新日 2023-12-13 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Mechanism of agonist-induced activation of the human itch receptor MRGPRX1. Plos Biol., 21, 2023
8HK5	C5aR1-Gi-C5a protein complex 分子名称: C5a anaphylatoxin chemotactic receptor 1, Complement C5, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK3	C3aR-Gi-apo protein complex 分子名称: C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8HK2	C3aR-Gi-C3a protein complex 分子名称: C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, CHOLESTEROL, ... 著者 Wang, Y, Liu, W, Xu, Y, Zhuang, Y, Xu, H.E. 登録日 2022-11-24 公開日 2023-05-10 最終更新日 2023-11-08 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Revealing the signaling of complement receptors C3aR and C5aR1 by anaphylatoxins. Nat.Chem.Biol., 19, 2023
8H4I	DHA-bound FFAR4 in complex with Gs 分子名称: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8H4L	DHA-bound FFAR4 in complex with Gq 分子名称: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8HMP	GPR52 with Gs and c17 分子名称: G-protein coupled receptor 52, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Chen, B, Xu, F. 登録日 2022-12-05 公開日 2023-06-21 実験手法 ELECTRON MICROSCOPY (2.77 Å) 主引用文献 Allosteric coupling between G-protein binding and extracellular ligand binding sites in GPR52 revealed by 19 F-NMR and cryo-electron microscopy. MedComm (2020), 4, 2023
8H4K	GW9508-bound FFAR4 in complex with Gq 分子名称: 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid, Free fatty acid receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 He, Y, Yin, H. 登録日 2022-10-10 公開日 2023-06-21 最終更新日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis of omega-3 fatty acid receptor FFAR4 activation and G protein coupling selectivity. Cell Res., 33, 2023
8H0P	Structure of the NMB30-NMBR and Gq complex 分子名称: G-alpha q, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. 登録日 2022-09-30 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.15 Å) 主引用文献 Molecular recognition of itch-associated neuropeptides by bombesin receptors Cell Res., 33, 2023
8H0Q	Structure of the GRP14-27-GRPR-Gq complex 分子名称: CHOLESTEROL, G-alpha q, GRP, ... 著者 Li, C, Xu, Y, Liu, H, Cai, H, Xu, H.E, Yin, W. 登録日 2022-09-30 公開日 2023-08-09 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Molecular recognition of itch-associated neuropeptides by bombesin receptors Cell Res., 33, 2023
8HQC	Structure of a GPCR-G protein in complex with a natural peptide agonist 分子名称: Antibody fragment, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 実験手法 ELECTRON MICROSCOPY (3.89 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8H2G	Cryo-EM structure of niacin bound human hydroxy-carboxylic acid receptor 2 in complex with Gi heterotrimer 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Park, J.H, Ishimoto, N, Park, S.Y. 登録日 2022-10-06 公開日 2023-10-11 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis for hydroxy-carboxylic acid receptor 2 activation and allosteric mechanism To Be Published
8HPT	Structure of C5a-pep bound mouse C5aR1 in complex with Go 分子名称: Antibody fragment ScFv16, C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Saha, S, Maharana, J, Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. 登録日 2022-12-13 公開日 2023-10-18 最終更新日 2023-11-15 実験手法 ELECTRON MICROSCOPY (3.39 Å) 主引用文献 Structure of a GPCR-G protein in complex with a synthetic peptide agonist Cell(Cambridge,Mass.), 2023
8HQN	Activation mechanism of GPR132 by 9(S)-HODE 分子名称: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HVI	Activation mechanism of GPR132 by compound NOX-6-7 分子名称: 3-methyl-5-[(4-oxidanylidene-4-phenyl-butanoyl)amino]-1-benzofuran-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-26 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (3.04 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HQE	Cryo-EM structure of the apo-GPR132-Gi 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HQM	Activation mechanism of GPR132 by NPGLY 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Wang, J.L, Ding, J.H, Sun, J.P, Yu, X. 登録日 2022-12-13 公開日 2023-10-11 最終更新日 2023-11-01 実験手法 ELECTRON MICROSCOPY (2.95 Å) 主引用文献 Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5, 2023
8HNK	CXCR3-DNGi complex activated by CXCL11 分子名称: C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiao, H.Z, Hu, H.L. 登録日 2022-12-08 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
8HNL	CXCR3-DNGi complex activated by PS372424 分子名称: (3S)-N-[(2S)-5-carbamimidamido-1-(cyclohexylmethylamino)-1-oxidanylidene-pentan-2-yl]-2-(4-oxidanylidene-4-phenyl-butanoyl)-3,4-dihydro-1H-isoquinoline-3-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Jiao, H.Z, Hu, H.L. 登録日 2022-12-08 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.98 Å) 主引用文献 Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
8HNM	CXCR3-DNGi complex activated by VUF11222 分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Jiao, H.Z, Hu, H.L. 登録日 2022-12-08 公開日 2023-11-29 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Structural insights into the activation and inhibition of CXC chemokine receptor 3. Nat.Struct.Mol.Biol., 31, 2024
8HTI	Human Consensus Olfactory Receptor OR52c in Complex with Octanoic Acid (OCA) and G Protein 分子名称: Consensus Olfactory Receptor OR52c, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Choi, C.W, Bae, J, Choi, H.-J, Kim, J. 登録日 2022-12-21 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (2.97 Å) 主引用文献 Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family. Nat Commun, 14, 2023
8HN8	Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. 登録日 2022-12-07 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit To Be Published
8HOC	Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex 分子名称: 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. 登録日 2022-12-09 公開日 2023-12-20 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit To Be Published
8HJ1	GPR21(wt) and Gs complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... 著者 Chen, B, Lin, X, Xu, F. 登録日 2022-11-22 公開日 2023-12-27 実験手法 ELECTRON MICROSCOPY (3.27 Å) 主引用文献 Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023

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