8HQC

Structure of a GPCR-G protein in complex with a natural peptide agonist

Summary for 8HQC

• Entry DOI: 10.2210/pdb8hqc/pdb
• EMDB information: 34947
• Descriptor: C5a anaphylatoxin chemotactic receptor 1, Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
• Functional Keywords: gpcr, g protein, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 6
• Total formula weight: 154007.55

Authors

Saha, S.,Maharana, J.,Yadav, M.K.,Sarma, P.,Chami, M.,Banerjee, R.,Shukla, A.K. (deposition date: 2022-12-13, release date: 2023-10-18, Last modification date: 2024-07-17)

• Primary citation: Yadav, M.K.,Maharana, J.,Yadav, R.,Saha, S.,Sarma, P.,Soni, C.,Singh, V.,Saha, S.,Ganguly, M.,Li, X.X.,Mohapatra, S.,Mishra, S.,Khant, H.A.,Chami, M.,Woodruff, T.M.,Banerjee, R.,Shukla, A.K.,Gati, C.; Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.; Cell, 186:4956-4973.e21, 2023; PubMed: 37852260; DOI: 10.1016/j.cell.2023.09.020

Experimental method

ELECTRON MICROSCOPY (3.89 Å)