8HN8

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

Summary for 8HN8

• Entry DOI: 10.2210/pdb8hn8/pdb
• EMDB information: 34908
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: gpcr complex, agonist, histamine receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 180427.15

Authors

Tang, W.Q.,Sun, X.Y.,Li, F.H.,Wang, J.Y. (deposition date: 2022-12-07, release date: 2023-12-20)

• Primary citation: Sun, X.Y.,Li, F.H.,Wang, J.Y.; Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3 Å)