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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8HN8

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AGuanine nucleotide-binding protein G(i) subunit alpha-1polymer35440415.01UniProt (P63096)
Pfam (PF00503)
In PDB		Homo sapiens (human)Adenylate cyclase-inhibiting G alpha protein
2BGuanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1polymer34037416.91UniProt (P62873)
Pfam (PF00400)
In PDB		Homo sapiens (human)Transducin beta chain 1
3GGuanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2polymer717861.11UniProt (P59768)
Pfam (PF00631)
In PDB		Homo sapiens (human)G gamma-I
4RSoluble cytochrome b562, Histamine H4 receptor fusionpolymer54962752.31UniProt (P0ABE7)
UniProt (Q9H3N8)
Pfam (PF07361)
Pfam (PF00001)
In PDB		Homo sapiens (human)Cytochrome b-562,H4R,HH4R,AXOR35,G-protein coupled receptor 105,GPRv53,Pfi-013,SP9144
5SSingle-chain variable fragment scFv16polymer29731870.61Homo sapiens (human)
6RHISTAMINEnon-polymer111.11Chemie (HSM)
Sequence modifications
R: -114 - -10 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Met -158-initiating methionine
Lys -157-expression tag
Thr -156-expression tag
Ile -155-expression tag
Ile -154-expression tag
Ala -153-expression tag
Leu -152-expression tag
Ser -151-expression tag
Tyr -150-expression tag
Ile -149-expression tag
Phe -148-expression tag
Cys -147-expression tag
Leu -146-expression tag
Val -145-expression tag
Phe -144-expression tag
Ala -143-expression tag
His -142-expression tag
His -141-expression tag
His -140-expression tag
His -139-expression tag
His -138-expression tag
His -137-expression tag
His -136-expression tag
His -135-expression tag
His -134-expression tag
His -133-expression tag
Asp -132-expression tag
Tyr -131-expression tag
Lys -130-expression tag
Asp -129-expression tag
Asp -128-expression tag
Asp -127-expression tag
Asp -126-expression tag
Lys -125-expression tag
Glu -124-expression tag
Asn -123-expression tag
Leu -122-expression tag
Tyr -121-expression tag
Phe -120-expression tag
Gln -119-expression tag
Ser -118-expression tag
Gly -117-expression tag
Ala -116-expression tag
Pro -115-expression tag
Trp -108Met 29conflict
Ile -13His 124conflict
Leu -9-linker
Glu -8-linker
Phe -7-linker
Leu -6-linker
Glu -5-linker
Val -4-linker
Leu -3-linker
Phe -2-linker
Gln -1-linker
Gly 0-linker
Pro 1-linker
Ser 2-linker
Ala 3-linker
R: 4 - 390 (UniProt: Q9H3N8)
PDBExternal DatabaseDetails
Ile 16Val 16conflict
Leu 21Phe 21conflict
Leu 25Val 25conflict
Val 35Leu 35conflict
Asn 51Ser 51conflict
Gln 114Leu 114conflict
Ile 129Val 129conflict
Leu 184Val 184conflict
Val 185Ile 185conflict
Tyr 196Asn 196conflict
Gly 205Asp 205conflict
Asn 206His 206conflict
Ser 218Ala 218conflict
Ser 222Asn 222conflict
Phe 233Ser 233conflict
Thr 236Arg 236conflict
Pro 239Ser 239conflict
Lys 242Thr 242conflict
Ala 245Pro 245conflict
Leu 260Met 260conflict
Leu 263Ser 263conflict
Gln 266Lys 266conflict
Ile 271Thr 271conflict
Leu 279Phe 279conflict
Leu 285Val 285conflict
Leu 293Val 293conflict
Lys 300Arg 300conflict
Pro 330Ser 330conflict
Arg 334Gly 334conflict
Phe 356Leu 356conflict
Ile 380Leu 380conflict
Asn 385Ser 385conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight180316.0
Non-Polymers*Number of molecules1
Total formula weight111.1
All*Total formula weight180427.2
*Water molecules are not included.

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PDB entries from 2024-07-10

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