8HVI
Activation mechanism of GPR132 by compound NOX-6-7
Summary for 8HVI
Entry DOI | 10.2210/pdb8hvi/pdb |
EMDB information | 35044 |
Descriptor | Soluble cytochrome b562,Probable G-protein coupled receptor 132, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total) |
Functional Keywords | gpcr, gpr132, membrane protein |
Biological source | Escherichia coli More |
Total number of polymer chains | 5 |
Total formula weight | 170396.83 |
Authors | Wang, J.L.,Ding, J.H.,Sun, J.P.,Yu, X. (deposition date: 2022-12-26, release date: 2023-10-11, Last modification date: 2023-11-01) |
Primary citation | Wang, J.L.,Dou, X.D.,Cheng, J.,Gao, M.X.,Xu, G.F.,Ding, W.,Ding, J.H.,Li, Y.,Wang, S.H.,Ji, Z.W.,Zhao, X.Y.,Huo, T.Y.,Zhang, C.F.,Liu, Y.M.,Sha, X.Y.,Gao, J.R.,Zhang, W.H.,Hao, Y.,Zhang, C.,Sun, J.P.,Jiao, N.,Yu, X. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5:1726-1746, 2023 Cited by PubMed: 37770763DOI: 10.1038/s42255-023-00899-4 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.04 Å) |
Structure validation
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