8HVI

Activation mechanism of GPR132 by compound NOX-6-7

Summary for 8HVI

Entry DOI	10.2210/pdb8hvi/pdb
EMDB information	35044
Descriptor	Soluble cytochrome b562,Probable G-protein coupled receptor 132, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (6 entities in total)
Functional Keywords	gpcr, gpr132, membrane protein
Biological source	Escherichia coli More
Total number of polymer chains	5
Total formula weight	170396.83
Authors	Wang, J.L.,Ding, J.H.,Sun, J.P.,Yu, X. (deposition date: 2022-12-26, release date: 2023-10-11, Last modification date: 2023-11-01)
Primary citation	Wang, J.L.,Dou, X.D.,Cheng, J.,Gao, M.X.,Xu, G.F.,Ding, W.,Ding, J.H.,Li, Y.,Wang, S.H.,Ji, Z.W.,Zhao, X.Y.,Huo, T.Y.,Zhang, C.F.,Liu, Y.M.,Sha, X.Y.,Gao, J.R.,Zhang, W.H.,Hao, Y.,Zhang, C.,Sun, J.P.,Jiao, N.,Yu, X. Functional screening and rational design of compounds targeting GPR132 to treat diabetes. Nat Metab, 5:1726-1746, 2023 Cited by PubMed: 37770763 DOI: 10.1038/s42255-023-00899-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.04 Å)

Structure validation