8HJ5

Cryo-EM structure of Gq-coupled MRGPRX1 bound with Compound-16

Summary for 8HJ5

• Entry DOI: 10.2210/pdb8hj5/pdb
• EMDB information: 34833
• Descriptor: Guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 208462.87

Authors

Gan, B.,Yu, L.Y.,Ren, R.B. (deposition date: 2022-11-22, release date: 2023-05-31, Last modification date: 2023-12-13)

• Primary citation: Gan, B.,Yu, L.,Yang, H.,Jiao, H.,Pang, B.,Chen, Y.,Wang, C.,Lv, R.,Hu, H.,Cao, Z.,Ren, R.; Mechanism of agonist-induced activation of the human itch receptor MRGPRX1.; Plos Biol., 21:e3001975-e3001975, 2023; PubMed: 37347749; DOI: 10.1371/journal.pbio.3001975

Experimental method

ELECTRON MICROSCOPY (3 Å)