PDB: 71425 件ウェブページステータス検索Chemie searchBIRD

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7P7B	SARS-CoV-2 spike protein in complex with sybody no68 in a 1up/2down conformation 分子名称: Spike glycoprotein 著者 Walter, J.D, Hutter, C.A.J, Garaeva, A.A, Scherer, M, Zimmermann, I, Wyss, M, Rheinberger, J, Ruedin, Y, Earp, J.C, Egloff, P, Sorgenfrei, M, Huerlimann, L.M, Gonda, I, Meier, G, Remm, S, Thavarasah, S, Zimmer, G, Slotboom, D.J, Paulino, C, Plattet, P, Seeger, M.A. 登録日 2021-07-19 公開日 2021-08-04 最終更新日 2022-04-20 実験手法 ELECTRON MICROSCOPY (3.13 Å) 主引用文献 Biparatopic sybodies neutralize SARS-CoV-2 variants of concern and mitigate drug resistance. Embo Rep., 23, 2022
5B5I	The crystal structure of a crustacean hyperglycemic hormone precursor from the kuruma prawn 分子名称: Crustacean hyperglycemic hormones 1, ETHANOL 著者 Tsutsui, N, Nagata, K. 登録日 2016-05-10 公開日 2016-10-19 最終更新日 2020-02-26 実験手法 X-RAY DIFFRACTION (1.599 Å) 主引用文献 Crystal structure of a crustacean hyperglycemic hormone (CHH) precursor suggests structural variety in the C-terminal regions of CHH superfamily members. FEBS J., 283, 2016
6BFA	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1553 分子名称: 1-{4-amino-3-[6-(cyclopropyloxy)naphthalen-2-yl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}-2-methylpropan-2-ol, Calmodulin-domain protein kinase 1 著者 Merritt, E.A. 登録日 2017-10-26 公開日 2017-12-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis. J. Med. Chem., 59, 2016
4ZYI	Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with cpd2 分子名称: (S)-7-((R)-sec-butoxy)-1-(4-chlorophenyl)-6-methoxy-2-(4-(methyl(pyridin-4-ylmethyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 著者 Kallen, J. 登録日 2015-05-21 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J.Med.Chem., 58, 2015
4ZYF	Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with NVP-CGM097 分子名称: (S)-1-(4-chlorophenyl)-7-isopropoxy-6-methoxy-2-(4-(methyl(((1r,4S)-4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl)methyl)amino)phenyl)-1,2-dihydroisoquinolin-3(4H)-one, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 著者 Kallen, J. 登録日 2015-05-21 公開日 2015-07-29 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J.Med.Chem., 58, 2015
1H2O	SOLUTION STRUCTURE OF THE MAJOR CHERRY ALLERGEN PRU AV 1 MUTANT E45W 分子名称: MAJOR ALLERGEN PRU AV 1 著者 Neudecker, P, Lehmann, K, Nerkamp, J, Schweimer, K, Sticht, H, Boehm, M, Scheurer, S, Vieths, S, Roesch, P. 登録日 2002-08-12 公開日 2003-08-28 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Mutational Epitope Analysis of Pru Av 1 and Api G 1, the Major Allergens of Cherry (Prunus Avium) and Celery (Apium Graveolens): Correlating Ige Reactivity with Three-Dimensional Structure Biochem.J., 376, 2003
3UV1	Crystal structure a major allergen from dust mite 分子名称: Der f 7 allergen 著者 Tan, K.W, Kumar, T, Chew, F.T, Mok, Y.K. 登録日 2011-11-29 公開日 2012-10-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Der f 7, a Dust Mite Allergen from Dermatophagoides farinae. Plos One, 7, 2012
1E09	Solution Structure of the Major Cherry Allergen Pru av 1 分子名称: PRU AV 1 著者 Neudecker, P, Nerkamp, J, Schweimer, K, Sticht, H, Boehm, M, Scheurer, S, Vieths, S, Roesch, P. 登録日 2000-03-15 公開日 2001-03-15 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Allergic Cross-Reactivity Made Visible: The Solution Structure of the Major Cherry Allergen Pru Av 1 J.Biol.Chem., 276, 2001
1CSE	THE HIGH-RESOLUTION X-RAY CRYSTAL STRUCTURE OF THE COMPLEX FORMED BETWEEN SUBTILISIN CARLSBERG AND EGLIN C, AN ELASTASE INHIBITOR FROM THE LEECH HIRUDO MEDICINALIS. STRUCTURAL ANALYSIS, SUBTILISIN STRUCTURE AND INTERFACE GEOMETRY 分子名称: CALCIUM ION, EGLIN C, SUBTILISIN CARLSBERG 著者 Bode, W. 登録日 1988-06-03 公開日 1988-07-16 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.2 Å) 主引用文献 The high-resolution X-ray crystal structure of the complex formed between subtilisin Carlsberg and eglin c, an elastase inhibitor from the leech Hirudo medicinalis. Structural analysis, subtilisin structure and interface geometry. Eur.J.Biochem., 166, 1987
1S6W	Solution Structure of hybrid white striped bass hepcidin 分子名称: Hepcidin 著者 Babon, J.J, Singh, S, Pennington, M.W, Norton, R.S, Westerman, M.E. 登録日 2004-01-28 公開日 2004-12-14 最終更新日 2022-03-02 実験手法 SOLUTION NMR 主引用文献 Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J.Biol.Chem., 280, 2005
1FCP	FERRIC HYDROXAMATE UPTAKE RECEPTOR (FHUA) FROM E.COLI IN COMPLEX WITH BOUND FERRICHROME-IRON 分子名称: 2-TRIDECANOYLOXY-PENTADECANOIC ACID, 3-OXO-PENTADECANOIC ACID, ACETOACETIC ACID, ... 著者 Hofmann, E, Ferguson, A.D, Diederichs, K, Welte, W. 登録日 1998-10-14 公開日 1999-01-13 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Siderophore-mediated iron transport: crystal structure of FhuA with bound lipopolysaccharide. Science, 282, 1998
3L4R	Crystal structure of the dog lipocalin allergen Can f 2 and implications for cross-reactivity to the cat allergen Fel d 4 分子名称: GLYCEROL, Minor allergen Can f 2 著者 Madhurantakam, C, Nilsson, O.B, Gronlund, H, Achour, A. 登録日 2009-12-21 公開日 2010-05-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 Crystal Structure of the Dog Lipocalin Allergen Can f 2: Implications for Cross-reactivity to the Cat Allergen Fel d 4 J.Mol.Biol., 401, 2010
2YCY	TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL 分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA-1 ADRENERGIC RECEPTOR, SODIUM ION, ... 著者 Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X. 登録日 2011-03-17 公開日 2011-06-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.15 Å) 主引用文献 Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor. Proc.Natl.Acad.Sci.USA, 108, 2011
2YCZ	TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL 分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, BETA-1 ADRENERGIC RECEPTOR, octyl 1-thio-beta-D-glucopyranoside 著者 Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X. 登録日 2011-03-17 公開日 2011-06-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3.65 Å) 主引用文献 Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor. Proc.Natl.Acad.Sci.USA, 108, 2011
8DB4	Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1 分子名称: 1,2-ETHANEDIOL, 13T1 Heavy chain, 13T1 Light chain, ... 著者 Min, J, Pedersen, L.C. 登録日 2022-06-14 公開日 2023-01-25 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy. J.Clin.Invest., 133, 2023
2YCW	TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL 分子名称: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, BETA-1 ADRENERGIC RECEPTOR, HEGA-10, ... 著者 Moukhametzianov, R, Warne, T, Edwards, P.C, Serrano-Vega, M.J, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X. 登録日 2011-03-17 公開日 2011-06-01 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor. Proc.Natl.Acad.Sci.USA, 108, 2011
2CFE	The 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family 分子名称: ALANINE, ALLERGEN, GLYCEROL, ... 著者 Limacher, A, Glaser, A.G, Fluckiger, S, Scheynius, A, Scapozza, L, Crameri, R. 登録日 2006-02-20 公開日 2006-02-22 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family. Biochem. J., 396, 2006
2YGU	Crystal structure of fire ant venom allergen, Sol I 2 分子名称: HEPTANE, VENOM ALLERGEN 2 著者 Borer, A.S, Wassmann, P, Schirmer, T, Markovic-Housley, Z. 登録日 2011-04-20 公開日 2011-11-23 最終更新日 2012-02-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal Structure of Sol I 2, a Major Allergen from Fire Ant Venom J.Mol.Biol., 415, 2012
5X7Y	Crystal Structure of the Dog Lipocalin Allergen Can f 6 分子名称: DI(HYDROXYETHYL)ETHER, Lipocalin-Can f 6 allergen 著者 Yamamoto, K, Otani, T, Sugiura, K, Nakatsuji, M, Nishimura, S, Inui, T. 登録日 2017-02-28 公開日 2018-04-04 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structure of the dog allergen Can f 6 and structure-based implications of its cross-reactivity with the cat allergen Fel d 4. Sci Rep, 9, 2019
8DCS	Cryo-EM structure of cyanopindolol-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein 分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. 登録日 2022-06-17 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.5 Å) 主引用文献 Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
8DCR	Cryo-EM structure of dobutamine-bound beta1-adrenergic receptor in complex with heterotrimeric Gs-protein 分子名称: DOBUTAMINE, Endolysin,Endolysin,Beta-1 adrenergic receptor chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Su, M, Paknejad, N, Hite, R.K, Huang, X.Y. 登録日 2022-06-17 公開日 2022-07-27 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structures of beta 1 -adrenergic receptor in complex with Gs and ligands of different efficacies. Nat Commun, 13, 2022
2VT4	TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL 分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA1 ADRENERGIC RECEPTOR, DECANE, ... 著者 Warne, A, Serrano-Vega, M.J, Baker, J.G, Moukhametzianov, R, Edwards, P.C, Henderson, R, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X. 登録日 2008-05-09 公開日 2008-06-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor. Nature, 454, 2008
7W6P	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a G protein biased agonist 分子名称: Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. 登録日 2021-12-02 公開日 2022-09-28 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.47 Å) 主引用文献 Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
7W7E	Cryo-EM structure of the alpha2A adrenergic receptor GoA signaling complex bound to a biased agonist 分子名称: 5-(3-bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine, Alpha-2A adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Xu, J, Fink, E.A, Shoichet, B.K, Du, Y. 登録日 2021-12-04 公開日 2022-09-28 最終更新日 2022-10-12 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure-based discovery of nonopioid analgesics acting through the alpha 2A -adrenergic receptor. Science, 377, 2022
2B5S	Crystal structure of peach Pru p3, the prototypic member of the family of plant non-specific lipid transfer protein pan-allergens 分子名称: HEPTANE, LAURIC ACID, Non-specific lipid transfer protein, ... 著者 Pasquato, N, Berni, R, Folli, C, Folloni, S, Cianci, M, Pantano, S, Helliwell, R.J, Zanotti, G. 登録日 2005-09-29 公開日 2005-11-29 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal Structure of Peach Pru p 3, the Prototypic Member of the Family of Plant Non-specific Lipid Transfer Protein Pan-allergens J.Mol.Biol., 356, 2006

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