2YCZ

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL

Summary for 2YCZ

Entry DOI	10.2210/pdb2ycz/pdb
Related	1DEP 2VT4 2Y00 2Y01 2Y02 2Y03 2Y04 2YCW 2YCX 2YCY
Descriptor	BETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, octyl 1-thio-beta-D-glucopyranoside (3 entities in total)
Functional Keywords	gpcr, receptor, transducer, antagonist bound form, integral membrane protein, g-protein coupled receptor, thermostabilising point mutations, seven-helix receptor, 7tm receptor
Biological source	MELEAGRIS GALLOPAVO (TURKEY)
Total number of polymer chains	2
Total formula weight	72640.14
Authors	Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.W.,Tate, C.G.,Schertler, G.F.X. (deposition date: 2011-03-17, release date: 2011-06-01, Last modification date: 2023-12-20)
Primary citation	Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.,Tate, C.G.,Schertler, G.F. Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor. Proc.Natl.Acad.Sci.USA, 108:8228-, 2011 Cited by PubMed: 21540331 DOI: 10.1073/PNAS.1100185108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.65 Å)

Structure validation