2YCZ

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST IODOCYANOPINDOLOL

Summary for 2YCZ

Related2VT4 2Y04 2Y00 2YCW 1DEP 2Y01 2YCX 2YCY 2Y02 2Y03
DescriptorBETA-1 ADRENERGIC RECEPTOR, 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3-iodo-1H-indole-2-carbonitrile, 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL (3 entities in total)
Functional Keywordsgpcr, receptor, transducer, antagonist bound form, integral membrane protein, g-protein coupled receptor, thermostabilising point mutations, seven-helix receptor, 7tm receptor
Biological sourceMELEAGRIS GALLOPAVO (TURKEY)
Cellular locationCell membrane; Multi-pass membrane protein P07700
Total number of polymer chains2
Total molecular weight72640.14
Authors
Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.W.,Tate, C.G.,Schertler, G.F.X. (deposition date: 2011-03-17, release date: 2011-06-01, Last modification date: 2011-07-13)
Primary citation
Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.,Tate, C.G.,Schertler, G.F.
Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a {Beta}1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108:8228-, 2011
PubMed: 21540331 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.1100185108
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.65 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.283100.2%1.0%3.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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Molmil generated image of 2ycz
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More Biological unit images

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Molmil generated image of 2ycz
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2ycz.pdb1.gz [50.21 KB])
Coordinate files for Biological unit (2ycz.pdb2.gz [50.66 KB])
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