2YCW

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL

Summary for 2YCW

Related1DEP 2Y01 2VT4 2Y04 2Y00 2Y03 2Y02 2YCX 2YCY 2YCZ
DescriptorBETA-1 ADRENERGIC RECEPTOR, (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, HEGA-10, ... (4 entities in total)
Functional Keywordsgpcr, receptor, transducer, antagonist bound form, integral membrane protein, g-protein coupled receptor, thermostabilising point mutations, seven-helix receptor, 7tm receptor
Biological sourceMELEAGRIS GALLOPAVO (TURKEY)
Cellular locationCell membrane; Multi-pass membrane protein P07700
Total number of polymer chains2
Total molecular weight74045.38
Authors
Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.W.,Tate, C.G.,Schertler, G.F.X. (deposition date: 2011-03-17, release date: 2011-06-01, Last modification date: 2011-07-13)
Primary citation
Moukhametzianov, R.,Warne, T.,Edwards, P.C.,Serrano-Vega, M.J.,Leslie, A.G.,Tate, C.G.,Schertler, G.F.
Two Distinct Conformations of Helix 6 Observed in Antagonist-Bound Structures of a Beta-1- Adrenergic Receptor.
Proc.Natl.Acad.Sci.USA, 108:8228-, 2011
PubMed: 21540331 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.1100185108
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.29590.8%5.6%6.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2ycw
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Molmil generated image of 2ycw
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Molmil generated image of 2ycw
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More Biological unit images

Molmil generated image of 2ycw
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Molmil generated image of 2ycw
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Molmil generated image of 2ycw
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2ycw.pdb2.gz [51.39 KB])
Coordinate files for Biological unit (2ycw.pdb1.gz [51.63 KB])
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