2YCW

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CARAZOLOL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004935	molecular_function	adrenergic receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
B	0004930	molecular_function	G protein-coupled receptor activity
B	0004935	molecular_function	adrenergic receptor activity
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CAU A 400

Chain	Residue
A	TRP117
A	ASN329
A	TYR333
A	ASP121
A	VAL122
A	PHE201
A	TYR207
A	SER211
A	SER215
A	PHE306
A	ASN310

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CAU B 400

Chain	Residue
B	TRP117
B	ASP121
B	PHE201
B	TYR207
B	SER211
B	PHE306
B	PHE307
B	ASN310
B	ASN329
B	TYR333

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 2CV A 1360

Chain	Residue
A	HIS286
A	LEU289
A	LYS290
A	MET296

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 2CV A 1361

Chain	Residue
A	PRO176
A	TRP181
A	GLU185
A	ASN204
A	ARG205
A	ALA206
B	VAL160
B	2CV1362

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 2CV B 1360

Chain	Residue
A	VAL160
A	THR164
B	TRP181
B	ALA206

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 2CV B 1362

Chain	Residue
A	2CV1361
B	ARG157
B	VAL160

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 1362

Chain	Residue
A	SER111
A	ASP195
A	CYS198

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NA B 1363

Chain	Residue
B	SER111
B	CYS192
B	ASP195
B	CYS198

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASIeTLCVIAIDRYLaI

Chain	Residue	Details
A	ALA127-ILE143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	GLN39-GLY67
B	GLN39-GLY67

---

site_id	SWS_FT_FI2
Number of Residues	156
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18594507

Chain	Residue	Details
A	SER68-THR76
A	ASP138-ARG155
A	ARG232-PHE315
B	SER68-THR76
B	ASP138-ARG155
B	ARG232-PHE315

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ASN77-VAL103
B	ASN77-VAL103

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:18594507

Chain	Residue	Details
A	ARG104-GLU115
A	HIS180-ARG205
A	ASN316-VAL320
B	ARG104-GLU115
B	HIS180-ARG205
B	ASN316-VAL320

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU116-ILE137
B	LEU116-ILE137

---

site_id	SWS_FT_FI6
Number of Residues	46
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA156-MET179
B	ALA156-MET179

---

site_id	SWS_FT_FI7
Number of Residues	50
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	ALA206-TYR231
B	ALA206-TYR231

---

site_id	SWS_FT_FI8
Number of Residues	58
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	HIS286-PHE315
B	HIS286-PHE315

---

site_id	SWS_FT_FI9
Number of Residues	44
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	PRO321-TYR343
B	PRO321-TYR343

---

site_id	SWS_FT_FI10
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4

Chain	Residue	Details
A	ASP121
A	SER211
A	ASN329
B	ASP121
B	SER211
B	ASN329

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain	Residue	Details
A	ALA358
B	ALA358

---