3UV1

Crystal structure a major allergen from dust mite

Summary for 3UV1

• Entry DOI: 10.2210/pdb3uv1/pdb
• Descriptor: Der f 7 allergen (2 entities in total)
• Functional Keywords: super-roll, allergen
• Biological source: Dermatophagoides farinae (American house dust mite)
• Total number of polymer chains: 2
• Total formula weight: 44394.74

Authors

Tan, K.W.,Kumar, T.,Chew, F.T.,Mok, Y.K. (deposition date: 2011-11-29, release date: 2012-10-17, Last modification date: 2024-10-30)

Primary citation

Tan, K.W.,Jobichen, C.,Ong, T.C.,Gao, Y.F.,Tiong, Y.S.,Wong, K.N.,Chew, F.T.,Sivaraman, J.,Mok, Y.K.
Crystal Structure of Der f 7, a Dust Mite Allergen from Dermatophagoides farinae.
Plos One, 7:e44850-e44850, 2012

PubMed Abstract: Der f 7 is the group 7 allergen from the dust mite Dermatophagoides farinae, homologous to the major allergen Der p 7 from D. pteronyssinus. Monoclonal antibody that bind to residues Leu48 and Phe50 was found to inhibit IgE binding to residue Asp159, which is important for the cross-reactivity between Der f 7 and Der p 7.

PubMed: 22970319
DOI: 10.1371/journal.pone.0044850

Experimental method

X-RAY DIFFRACTION (2 Å)