8DB4
Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1
Summary for 8DB4
Entry DOI | 10.2210/pdb8db4/pdb |
Descriptor | 13T1 Heavy chain, 13T1 Light chain, 22S1 Heavy chain, ... (8 entities in total) |
Functional Keywords | antibody, immunotherapy, immunoglobulin, allergen-immune system complex, allergen/immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 10 |
Total formula weight | 223644.62 |
Authors | Min, J.,Pedersen, L.C. (deposition date: 2022-06-14, release date: 2023-01-25, Last modification date: 2023-10-25) |
Primary citation | LaHood, N.A.,Min, J.,Keswani, T.,Richardson, C.M.,Amoako, K.,Zhou, J.,Marini-Rapoport, O.,Bernard, H.,Hazebrouck, S.,Shreffler, W.G.,Love, J.C.,Pomes, A.,Pedersen, L.C.,Mueller, G.A.,Patil, S.U. Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy. J.Clin.Invest., 133:-, 2023 Cited by PubMed: 36647835DOI: 10.1172/JCI164501 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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