8DB4

Crystal structure of the peanut allergen Ara h 2 bound by two neutralizing antibodies 22S1 and 13T1

Summary for 8DB4

• Entry DOI: 10.2210/pdb8db4/pdb
• Descriptor: 13T1 Heavy chain, 13T1 Light chain, 22S1 Heavy chain, ... (8 entities in total)
• Functional Keywords: antibody, immunotherapy, immunoglobulin, allergen-immune system complex, allergen/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 223644.62

Authors

Min, J.,Pedersen, L.C. (deposition date: 2022-06-14, release date: 2023-01-25, Last modification date: 2023-10-25)

• Primary citation: LaHood, N.A.,Min, J.,Keswani, T.,Richardson, C.M.,Amoako, K.,Zhou, J.,Marini-Rapoport, O.,Bernard, H.,Hazebrouck, S.,Shreffler, W.G.,Love, J.C.,Pomes, A.,Pedersen, L.C.,Mueller, G.A.,Patil, S.U.; Immunotherapy-induced neutralizing antibodies disrupt allergen binding and sustain allergen tolerance in peanut allergy.; J.Clin.Invest., 133:-, 2023; PubMed: 36647835; DOI: 10.1172/JCI164501

Experimental method

X-RAY DIFFRACTION (2.3 Å)