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7T94
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Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM
分子名称: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ...
著者Xu, J, Wang, Q, Du, Y, Kobilka, B.K.
登録日2021-12-17
公開日2023-01-25
最終更新日2024-02-07
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun, 14, 2023
8KGK
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Cryo-EM structure of the GPR61-Gs complex
分子名称: G-protein coupled receptor 61, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Nie, Y, Qiu, Z, Zheng, S.
登録日2023-08-19
公開日2023-10-11
実験手法ELECTRON MICROSCOPY (3.16 Å)
主引用文献Specific binding of GPR174 by endogenous lysophosphatidylserine leads to high constitutive G s signaling.
Nat Commun, 14, 2023
6OMM
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Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C.
登録日2019-04-19
公開日2020-02-26
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling.
Nat Commun, 11, 2020
8IWM
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Cryo-EM structure of the PEA-bound mTAAR9 complex
分子名称: 2-PHENYLETHYLAMINE, Trace amine-associated receptor 9
著者Sun, J.P, Li, Q, Yang, F, Xu, Y.F, Guo, L.L, Lian, S, Zhang, M.H, Rong, N.K.
登録日2023-03-30
公開日2023-05-31
最終更新日2023-06-14
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Structural basis of amine odorant perception by a mammal olfactory receptor.
Nature, 618, 2023
8JII
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Cryo-EM structure of compound 9n and niacin bound ketone body receptor HCAR2-Gi signaling complex
分子名称: 7-methyl-N-[(2R)-1-phenoxypropan-2-yl]-3-(4-propan-2-ylphenyl)pyrazolo[1,5-a]pyrimidine-6-carboxamide, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H.
登録日2023-05-26
公開日2023-09-06
最終更新日2023-09-27
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Mol.Cell, 83, 2023
7SQO
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Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者McGrath, A.P, Kang, Y, Flinspach, M.
登録日2021-11-05
公開日2022-05-25
最終更新日2022-07-06
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Molecular mechanism of the wake-promoting agent TAK-925.
Nat Commun, 13, 2022
8I9L
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Structure of C3a-C3aR-Go complex (Composite map)
分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin, C3a anaphylatoxin chemotactic receptor, ...
著者Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C.
登録日2023-02-07
公開日2023-10-18
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (3.18 Å)
主引用文献Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
6PEL
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Crystal structure of bovine opsin with citronellol bound
分子名称: (3R)-3,7-dimethyloct-6-en-1-ol, ILENLKDVGLF G alpha peptide CT2, PALMITIC ACID, ...
著者Eger, B.T, Morizumi, T, Ernst, O.P.
登録日2019-06-20
公開日2020-06-24
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.186 Å)
主引用文献Odorant-binding site in visual opsin
To Be Published
6DS0
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Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
分子名称: (1S)-1-[(2-chloro-3,4-dimethoxyphenyl)methyl]-6-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5HT2B receptor, ...
著者McCorvy, J.D, Wacker, D, Wang, S, Agegnehu, B, Liu, J, Lansu, K, Tribo, A.R, Olsen, R.H.J, Che, T, Jin, J, Roth, B.L.
登録日2018-06-13
公開日2018-08-29
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.188 Å)
主引用文献Structural determinants of 5-HT2Breceptor activation and biased agonism.
Nat. Struct. Mol. Biol., 25, 2018
8X17
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Cryo-EM structure of adenosine receptor A3AR bound to CF102
分子名称: Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Cai, H, Xu, Y, Xu, H.E.
登録日2023-11-06
公開日2024-04-24
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Cryo-EM structures of adenosine receptor A 3 AR bound to selective agonists.
Nat Commun, 15, 2024
8IBV
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Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ...
著者Jiang, Y, Xu, H.E, You, C, Xu, Y.
登録日2023-02-10
公開日2023-04-12
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structural basis for motilin and erythromycin recognition by motilin receptor.
Sci Adv, 9, 2023
8ZH8
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Human GPR103 -Gq complex bound to QRFP26
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Iwama, A, Akasaka, H, Sano, F.K, Oshima, H.S, Shihoya, W, Nureki, O.
登録日2024-05-10
公開日2024-07-03
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103.
Nat Commun, 15, 2024
8I97
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BU of 8i97 by Molmil
Structure of Apo-C3aR-Go complex (Glacios)
分子名称: Antibody fragment - ScFv16, C3a anaphylatoxin chemotactic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C.
登録日2023-02-06
公開日2023-10-18
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
7T6B
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BU of 7t6b by Molmil
Structure of S1PR2-heterotrimeric G13 signaling complex
分子名称: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, X, Chen, H.
登録日2021-12-13
公開日2022-04-06
最終更新日2022-06-29
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structure of S1PR2-heterotrimeric G 13 signaling complex.
Sci Adv, 8, 2022
7X1U
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BU of 7x1u by Molmil
Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH.
分子名称: Endogenous Peptide Agonist TRH, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Yang, F, Zhang, H.H, Meng, X.Y, Li, Y.G, Zhou, Y.X, Ling, S.L, Liu, L, Shi, P, Tian, C.L.
登録日2022-02-24
公開日2022-08-31
最終更新日2022-09-14
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue.
Cell Res., 32, 2022
8F7W
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BU of 8f7w by Molmil
Gi bound kappa-opioid receptor in complex with dynorphin
分子名称: CHOLESTEROL, Dynorphin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
登録日2022-11-20
公開日2022-12-14
最終更新日2023-02-01
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structures of the entire human opioid receptor family.
Cell, 186, 2023
7YJ4
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BU of 7yj4 by Molmil
Cryo-EM structure of the INSL5-bound human relaxin family peptidereceptor 4 (RXFP4)-Gi complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ...
著者Chen, Y, Zhou, Q.T, Wang, J, Xu, Y.W, Wang, Y, Yan, J.H, Wang, Y.B, Zhu, Q, Zhao, F.H, Li, C.H, Chen, C.W, Cai, X.Q, Bathgate, R.A.D, Shen, C, Liu, H, Xu, H.E, Yang, D.H, Wang, M.W.
登録日2022-07-19
公開日2023-03-01
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Nat Commun, 14, 2023
6Z66
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Crystal structure of apo-state neurotensin receptor 1
分子名称: Neurotensin receptor type 1,Neurotensin receptor type 1,DARPin
著者Deluigi, M, Klipp, A, Hilge, M, Merklinger, L, Klenk, C, Plueckthun, A.
登録日2020-05-27
公開日2021-02-10
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.192 Å)
主引用文献Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
Sci Adv, 7, 2021
8XGR
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ETB-eGt complex bound to endothelin-1
分子名称: Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ...
著者Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O.
登録日2023-12-15
公開日2024-04-03
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application.
Biochem.Biophys.Res.Commun., 693, 2024
8X63
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CryoEM structure of the histamine H1 receptor-BRIL/Anti BRIL Fab complex with mepyramine
分子名称: Histamine H1 receptor,Soluble cytochrome b562, mepyramine
著者Wang, D.D, Guo, Q.
登録日2023-11-20
公開日2024-01-17
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Molecular mechanism of antihistamines recognition and regulation of the histamine H 1 receptor.
Nat Commun, 15, 2024
8WU1
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Cryo-EM structure of CB1-beta-arrestin1 complex
分子名称: Beta-arrestin-1, Cannabinoid receptor 1,Vasopressin V2 receptor, Fab30 heavy chain, ...
著者Liao, Y, Zhang, H, Shen, Q, Cai, C.
登録日2023-10-19
公開日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure of CB1-beta-arrestin1 complex
to be published
8XOH
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Cryo-EM structure of GPR30-Gq complex structure in the presence of E2
分子名称: G-protein coupled estrogen receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Liu, H, Xu, P, Xu, H.E.
登録日2024-01-01
公開日2024-04-10
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and functional evidence that GPR30 is not a direct estrogen receptor.
Cell Res., 34, 2024
8WC9
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Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex
分子名称: 2-(4-bromophenyl)ethanamine, Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日2023-09-11
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
8WC6
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Cryo-EM structure of the PEA-bound mTAAR1-Gs complex
分子名称: 2-PHENYLETHYLAMINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Rong, N.K, Guo, L.L, Zhang, M.H, Li, Q, Yang, F, Sun, J.P.
登録日2023-09-11
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.
Cell, 186, 2023
8QOT
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Structure of the mu opioid receptor bound to the antagonist nanobody NbE
分子名称: Anti-Fab Nanobody, Mu-type opioid receptor, NabFab HC, ...
著者Yu, J, Kumar, A, Zhang, X, Martin, C, Raia, P, Manglik, A, Ballet, S, Boland, A, Stoeber, M.
登録日2023-09-29
公開日2023-12-27
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural Basis of mu-Opioid Receptor-Targeting by a Nanobody Antagonist.
Biorxiv, 2023

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件を2024-07-17に公開中

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