8WC6

Cryo-EM structure of the PEA-bound mTAAR1-Gs complex

Summary for 8WC6

• Entry DOI: 10.2210/pdb8wc6/pdb
• EMDB information: 37432
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Nanobody-35, ... (7 entities in total)
• Functional Keywords: pea, mtaar1, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 169814.56

Authors

Rong, N.K.,Guo, L.L.,Zhang, M.H.,Li, Q.,Yang, F.,Sun, J.P. (deposition date: 2023-09-11, release date: 2023-12-27)

• Primary citation: Shang, P.,Rong, N.,Jiang, J.J.,Cheng, J.,Zhang, M.H.,Kang, D.,Qi, L.,Guo, L.,Yang, G.M.,Liu, Q.,Zhou, Z.,Li, X.B.,Zhu, K.K.,Meng, Q.B.,Han, X.,Yan, W.,Kong, Y.,Yang, L.,Wang, X.,Lei, D.,Feng, X.,Liu, X.,Yu, X.,Wang, Y.,Li, Q.,Shao, Z.H.,Yang, F.,Sun, J.P.; Structural and signaling mechanisms of TAAR1 enabled preferential agonist design.; Cell, 186:5347-5362.e24, 2023; PubMed: 37963465; DOI: 10.1016/j.cell.2023.10.014

Experimental method

ELECTRON MICROSCOPY (3.2 Å)