8WC6
Cryo-EM structure of the PEA-bound mTAAR1-Gs complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 362 | 42010.7 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63096) UniProt (by SIFTS) (P63092) | Homo sapiens (human) | |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 345 | 37915.5 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (N) | Nanobody-35 | polymer | 128 | 13885.4 | 1 | synthetic construct | ||
| 4 | D (R) | Trace amine-associated receptor 1 | polymer | 332 | 37656.6 | 1 | UniProt (Q923Y8) Pfam (PF00001) | Mus musculus (house mouse) | TaR-1,Trace amine receptor 1 |
| 5 | E (S) | scFv16 | polymer | 285 | 30363.0 | 1 | synthetic construct | ||
| 6 | F (Y) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (human) | G gamma-I |
| 7 | G (R) | 2-PHENYLETHYLAMINE | non-polymer | 122.2 | 1 | Chemie (PEA) |
Sequence modifications
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Met -4 | - | initiating methionine |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169692.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 122.2 | |
| All* | Total formula weight | 169814.6 |
