8WC9

Cryo-EM structure of the ZH8651-bound mTAAR1-Gq complex

Summary for 8WC9

Entry DOI	10.2210/pdb8wc9/pdb
EMDB information	37435
Descriptor	Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Trace amine-associated receptor 1, ... (6 entities in total)
Functional Keywords	zh8651, mtaar1, gq, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	155704.73
Authors	Rong, N.K.,Guo, L.L.,Zhang, M.H.,Li, Q.,Yang, F.,Sun, J.P. (deposition date: 2023-09-11, release date: 2023-12-27)
Primary citation	Shang, P.,Rong, N.,Jiang, J.J.,Cheng, J.,Zhang, M.H.,Kang, D.,Qi, L.,Guo, L.,Yang, G.M.,Liu, Q.,Zhou, Z.,Li, X.B.,Zhu, K.K.,Meng, Q.B.,Han, X.,Yan, W.,Kong, Y.,Yang, L.,Wang, X.,Lei, D.,Feng, X.,Liu, X.,Yu, X.,Wang, Y.,Li, Q.,Shao, Z.H.,Yang, F.,Sun, J.P. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186:5347-5362.e24, 2023 Cited by PubMed: 37963465 DOI: 10.1016/j.cell.2023.10.014 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation