PDB: 345 件ウェブページステータス検索Chemie searchBIRD

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1ML9	Structure of the Neurospora SET domain protein DIM-5, a histone lysine methyltransferase 分子名称: Histone H3 methyltransferase DIM-5, UNKNOWN, ZINC ION 著者 Zhang, X, Tamaru, H, Khan, S.I, Horton, J.R, Keefe, L.J, Selker, E.U, Cheng, X. 登録日 2002-08-30 公開日 2002-10-23 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase Cell(Cambridge,Mass.), 111, 2002
2R3A	Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 分子名称: Histone-lysine N-methyltransferase SUV39H2, S-ADENOSYLMETHIONINE, SERINE, ... 著者 Lunin, V.V, Wu, H, Zeng, H, Ren, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Min, J, Structural Genomics Consortium (SGC) 登録日 2007-08-29 公開日 2007-09-11 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
5EG2	SET7/9 N265A in complex with AdoHcy and TAF10 peptide 分子名称: Histone-lysine N-methyltransferase SETD7, S-ADENOSYL-L-HOMOCYSTEINE, SODIUM ION, ... 著者 Kroner, G.M, Fick, R.J, Trievel, R.C. 登録日 2015-10-26 公開日 2016-01-13 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Sulfur-Oxygen Chalcogen Bonding Mediates AdoMet Recognition in the Lysine Methyltransferase SET7/9. Acs Chem.Biol., 11, 2016
8OWO	SMYD3 in complex with fragment FL01507 分子名称: 3-oxidanylbenzenecarbonitrile, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Lund, B.A, Cederfelt, D, Dobritzsch, D. 登録日 2023-04-28 公開日 2023-08-30 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening. Rsc Med Chem, 15, 2024
2O8J	Human euchromatic histone methyltransferase 2 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-12-12 公開日 2007-01-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
1H3I	Crystal structure of the Histone Methyltransferase SET7/9 分子名称: HISTONE H3 LYSINE 4 SPECIFIC METHYLTRANSFERASE, MAGNESIUM ION 著者 Wilson, J.R, Jing, C, Walker, P.A, Martin, S.R, Howell, S.A, Blackburn, G.M, Gamblin, S.J, Xiao, B. 登録日 2002-09-04 公開日 2002-11-11 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure and Functional Analysis of the Histone Methyltransferase Set7/9 Cell(Cambridge,Mass.), 111, 2002
4QEO	crystal structure of KRYPTONITE in complex with mCHH DNA, H3(1-15) peptide and SAH 分子名称: DNA 5'-ACTGATGAGTACCAT-3', DNA 5'-GGTACT(5CM)ATCAGTAT-3', Histone H3, ... 著者 Du, J, Li, S, Patel, D.J. 登録日 2014-05-17 公開日 2014-07-30 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE. Mol.Cell, 55, 2014
6OX0	SETD3 in Complex with an Actin Peptide with Sinefungin Replacing SAH as Cofactor 分子名称: 1,2-ETHANEDIOL, Actin Peptide, Histone-lysine N-methyltransferase setd3, ... 著者 Horton, J.R, Dai, S, Cheng, X. 登録日 2019-05-13 公開日 2019-08-21 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.755 Å) 主引用文献 Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun, 10, 2019
6O9O	Crystal Structure of SMYD3 with Potent and Selective Isoxazole Amide Inhibitor 1 分子名称: 5-cyclopropyl-N-{1-[({trans-4-[(4,4,4-trifluorobutyl)amino]cyclohexyl}methyl)sulfonyl]piperidin-4-yl}-1,2-oxazole-3-carboxamide, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Elkins, P.A, Wang, L. 登録日 2019-03-14 公開日 2020-03-18 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.586 Å) 主引用文献 Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors To be published
6KQQ	NSD1 SET domain in complex with BT3 and SAM 分子名称: 2-azanyl-6-[(2-azanyl-4-oxidanyl-1,3-benzothiazol-6-yl)disulfanyl]-1,3-benzothiazol-4-ol, 2-azanyl-6-sulfanyl-1,3-benzothiazol-4-ol, CALCIUM ION, ... 著者 Cho, H.J, Cierpicki, T. 登録日 2019-08-18 公開日 2020-09-02 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Covalent inhibition of NSD1 histone methyltransferase. Nat.Chem.Biol., 16, 2020
3CBO	SET7/9-ER-AdoHcy complex 分子名称: BETA-MERCAPTOETHANOL, Estrogen receptor, GLYCEROL, ... 著者 Cheng, X, Jia, D. 登録日 2008-02-22 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol.Cell, 30, 2008
3CBM	SET7/9-ER-AdoMet complex 分子名称: BETA-MERCAPTOETHANOL, Estrogen receptor, Histone-lysine N-methyltransferase SETD7, ... 著者 Cheng, X, Jia, D. 登録日 2008-02-22 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.69 Å) 主引用文献 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol.Cell, 30, 2008
6KQP	NSD1 SET domain in complex with SAM 分子名称: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ... 著者 Cho, H.J, Cierpicki, T. 登録日 2019-08-18 公開日 2020-09-02 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Covalent inhibition of NSD1 histone methyltransferase. Nat.Chem.Biol., 16, 2020
2IGQ	Human euchromatic histone methyltransferase 1 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, euchromatic histone methyltransferase 1 著者 Min, J, Wu, H, Antoshenko, T, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2006-09-23 公開日 2006-10-24 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
6YUH	Crystal structure of SMYD3 with diperodon R enantiomer bound to allosteric site 分子名称: Diperodon, GLYCEROL, Histone-lysine N-methyltransferase SMYD3, ... 著者 Cederfelt, D, Talibov, V.O, Dobritzsch, D, Danielson, U.H. 登録日 2020-04-27 公開日 2021-01-13 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Discovery of an Allosteric Ligand Binding Site in SMYD3 Lysine Methyltransferase. Chembiochem, 22, 2021
1XQH	Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH 分子名称: 9-mer peptide from tumor protein p53, Histone-lysine N-methyltransferase, H3 lysine-4 specific, ... 著者 Chuikov, S, Kurash, J.K, Wilson, J.R, Xiao, B, Justin, N, Ivanov, G.S, McKinney, K, Tempst, P, Prives, C, Gamblin, S.J, Barlev, N.A, Reinberg, D. 登録日 2004-10-12 公開日 2004-11-23 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Regulation of p53 activity through lysine methylation Nature, 432, 2004
6Z2A	Structure of Clr4 mutant - F256A/F310A/F427A bound to SAH 分子名称: Histone-lysine N-methyltransferase, H3 lysine-9 specific, MAGNESIUM ION, ... 著者 Stirpe, A, Schalch, T. 登録日 2020-05-15 公開日 2021-05-26 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.456 Å) 主引用文献 SUV39 SET domains mediate crosstalk of heterochromatic histone marks. Elife, 10, 2021
2F69	Ternary complex of SET7/9 bound to AdoHcy and a TAF10 peptide 分子名称: Histone-lysine N-methyltransferase, H3 lysine-4 specific SET7, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Couture, J.-F, Collazo, E, Hauk, G, Trievel, R.C. 登録日 2005-11-28 公開日 2006-01-17 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structural basis for the methylation site specificity of SET7/9 Nat.Struct.Mol.Biol., 13, 2006
3BO5	Crystal structure of methyltransferase domain of human Histone-lysine N-methyltransferase SETMAR 分子名称: GLYCEROL, Histone-lysine N-methyltransferase SETMAR, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Lunin, V.V, Wu, H, Ren, H, Dobrovetsky, E, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Min, J, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2007-12-17 公開日 2008-01-22 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 The Crystal Structure of Methyltransferase Domain of Human Histone-lysine N-methyltransferase SETMAR in Complex With AdoHcy. To be Published
3CBP	Set7/9-ER-Sinefungin complex 分子名称: BETA-MERCAPTOETHANOL, Estrogen receptor, GLYCEROL, ... 著者 Cheng, X, Jia, D. 登録日 2008-02-22 公開日 2008-05-13 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase. Mol.Cell, 30, 2008
4E47	SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine 分子名称: (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, BETA-MERCAPTOETHANOL, Histone-lysine N-methyltransferase SETD7, ... 著者 Walker, J.R, Ouyang, H, Dong, A, Fish, P, Cook, A, Barsyte, D, Vedadi, M, Tatlock, J, Owen, D, Bunnage, M, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Structural Genomics Consortium (SGC) 登録日 2012-03-12 公開日 2012-03-28 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Setd7 in Complex with Inhibitor and SAM To be Published
2RFI	Crystal structure of catalytic domain of human euchromatic histone methyltransferase 1 in complex with SAH and dimethylated H3K9 peptide 分子名称: Histone H3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, ... 著者 Min, J, Wu, H, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) 登録日 2007-09-30 公開日 2007-10-23 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.59 Å) 主引用文献 Structural biology of human H3K9 methyltransferases Plos One, 5, 2010
4FMU	Crystal structure of Methyltransferase domain of human SET domain-containing protein 2 Compound: Pr-SNF 分子名称: (2S,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-(propylamino)hexanoic acid, Histone-lysine N-methyltransferase SETD2, UNKNOWN ATOM OR ION, ... 著者 Dong, A, Zeng, H, Ibanez, G, Zheng, W, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-06-18 公開日 2012-09-05 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134, 2012
4H12	The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine 分子名称: CHLORIDE ION, Histone-lysine N-methyltransferase SETD2, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Amaya, M.F, Dong, A, Zeng, H, Mackenzie, F, Bunnage, M, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2012-09-10 公開日 2012-10-03 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.06 Å) 主引用文献 Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134, 2012
8FBG	Crystal structure of NSD1 Mutant-Y1869C 分子名称: CALCIUM ION, Histone-lysine N-methyltransferase, H3 lysine-36 specific, ... 著者 Providokhina, K, Dong, A, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) 登録日 2022-11-29 公開日 2023-01-18 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Crystal structure of NSD1 To Be Published

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