4E47
SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine
Summary for 4E47
Entry DOI | 10.2210/pdb4e47/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD7, S-ADENOSYLMETHIONINE, (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide, ... (6 entities in total) |
Functional Keywords | ternary complex, set domain, methyltransferase, inhibitor, s-adenosylmethionine, chromatin regulator, chromosomal protein, nucleus, transcription, transcription regulation, transferase, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: Q8WTS6 |
Total number of polymer chains | 4 |
Total formula weight | 122257.92 |
Authors | Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Weigelt, J.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) (deposition date: 2012-03-12, release date: 2012-03-28, Last modification date: 2023-09-13) |
Primary citation | Walker, J.R.,Ouyang, H.,Dong, A.,Fish, P.,Cook, A.,Barsyte, D.,Vedadi, M.,Tatlock, J.,Owen, D.,Bunnage, M.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Brown, P.J.,Structural Genomics Consortium (SGC) Setd7 in Complex with Inhibitor and SAM To be Published, |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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