4E47
SET7/9 in complex with inhibitor (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6- sulfonamide and S-adenosylmethionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Histone-lysine N-methyltransferase SETD7 | polymer | 264 | 29684.0 | 4 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (human) | SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7 |
| 2 | E, I, K, M (A, B, C, D) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 4 | Chemie (SAM) | |||
| 3 | F, J, L, N (A, B, C, D) | (R)-(3-(3-cyanophenyl)-1-oxo-1-(pyrrolidin-1-yl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide | non-polymer | 438.5 | 4 | Chemie (0N6) | |||
| 4 | G (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 5 | H (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 857 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 109 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118735.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3522.1 | |
| All* | Total formula weight | 122257.9 |
