8OWO

SMYD3 in complex with fragment FL01507

Replaces:  7QA6

Summary for 8OWO

• Entry DOI: 10.2210/pdb8owo/pdb
• Related: 7QLB 7QNR 7QNU
• Descriptor: Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ZINC ION, ... (6 entities in total)
• Functional Keywords: methyltransferase, epigenetic, oncogen, histone, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 50266.28

Authors

Lund, B.A.,Cederfelt, D.,Dobritzsch, D. (deposition date: 2023-04-28, release date: 2023-08-30, Last modification date: 2024-04-24)

• Primary citation: FitzGerald, E.A.,Cederfelt, D.,Lund, B.A.,Myers, N.,Zhang, H.,Dobritzsch, D.,Danielson, H.; Identification of fragments targeting SMYD3 using highly sensitive kinetic and multiplexed biosensor-based screening; Rsc Med Chem, 2024; DOI: 10.1039/D4MD00093E

Experimental method

X-RAY DIFFRACTION (1.8 Å)