6KQQ
NSD1 SET domain in complex with BT3 and SAM
Summary for 6KQQ
| Entry DOI | 10.2210/pdb6kqq/pdb |
| Descriptor | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, 2-azanyl-6-sulfanyl-1,3-benzothiazol-4-ol, ... (8 entities in total) |
| Functional Keywords | histone-methyltransferase, sam, inhibitor complex, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 52880.55 |
| Authors | Cho, H.J.,Cierpicki, T. (deposition date: 2019-08-18, release date: 2020-09-02, Last modification date: 2022-03-23) |
| Primary citation | Huang, H.,Howard, C.A.,Zari, S.,Cho, H.J.,Shukla, S.,Li, H.,Ndoj, J.,Gonzalez-Alonso, P.,Nikolaidis, C.,Abbott, J.,Rogawski, D.S.,Potopnyk, M.A.,Kempinska, K.,Miao, H.,Purohit, T.,Henderson, A.,Mapp, A.,Sulis, M.L.,Ferrando, A.,Grembecka, J.,Cierpicki, T. Covalent inhibition of NSD1 histone methyltransferase. Nat.Chem.Biol., 16:1403-1410, 2020 Cited by PubMed: 32868895DOI: 10.1038/s41589-020-0626-6 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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