4H12
The crystal structure of methyltransferase domain of human SET domain-containing protein 2 in complex with S-adenosyl-L-homocysteine
Replaces: 3H6LSummary for 4H12
Entry DOI | 10.2210/pdb4h12/pdb |
Descriptor | Histone-lysine N-methyltransferase SETD2, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total) |
Functional Keywords | methyltransferase, set domain-containing protein 2, s-adenosyl-l-homocysteine, structural genomics, structural genomics consortium, sgc, activator, chromatin regulator, dna-binding, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus (Probable): Q9BYW2 |
Total number of polymer chains | 1 |
Total formula weight | 32571.58 |
Authors | Amaya, M.F.,Dong, A.,Zeng, H.,Mackenzie, F.,Bunnage, M.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (deposition date: 2012-09-10, release date: 2012-10-03, Last modification date: 2023-09-13) |
Primary citation | Zheng, W.,Ibanez, G.,Wu, H.,Blum, G.,Zeng, H.,Dong, A.,Li, F.,Hajian, T.,Allali-Hassani, A.,Amaya, M.F.,Siarheyeva, A.,Yu, W.,Brown, P.J.,Schapira, M.,Vedadi, M.,Min, J.,Luo, M. Sinefungin Derivatives as Inhibitors and Structure Probes of Protein Lysine Methyltransferase SETD2. J.Am.Chem.Soc., 134:18004-18014, 2012 Cited by PubMed: 23043551DOI: 10.1021/ja307060p PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.06 Å) |
Structure validation
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