6KQP

NSD1 SET domain in complex with SAM

Summary for 6KQP

Entry DOI	10.2210/pdb6kqp/pdb
Descriptor	Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ZINC ION, ... (4 entities in total)
Functional Keywords	histone-methyltransferase, sam complex, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	25590.22
Authors	Cho, H.J.,Cierpicki, T. (deposition date: 2019-08-18, release date: 2020-09-02, Last modification date: 2023-11-22)
Primary citation	Huang, H.,Howard, C.A.,Zari, S.,Cho, H.J.,Shukla, S.,Li, H.,Ndoj, J.,Gonzalez-Alonso, P.,Nikolaidis, C.,Abbott, J.,Rogawski, D.S.,Potopnyk, M.A.,Kempinska, K.,Miao, H.,Purohit, T.,Henderson, A.,Mapp, A.,Sulis, M.L.,Ferrando, A.,Grembecka, J.,Cierpicki, T. Covalent inhibition of NSD1 histone methyltransferase. Nat.Chem.Biol., 16:1403-1410, 2020 Cited by PubMed: 32868895 DOI: 10.1038/s41589-020-0626-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation