6KQP

NSD1 SET domain in complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0042054	molecular_function	histone methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue SAM A 2101

Chain	Residue
A	ARG1952
A	TYR2058
A	ASN2065
A	VAL2069
A	CYS2070
A	LYS2071
A	HOH2209
A	TRP1954
A	THR1994
A	ASN1995
A	PHE1996
A	TYR1997
A	ARG2017
A	ASN2020
A	HIS2021

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 2102

Chain	Residue
A	CYS2023
A	CYS2070
A	CYS2072
A	CYS2077

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 2103

Chain	Residue
A	CYS1905
A	CYS1920
A	CYS1925
A	CYS1931

---

site_id	AC4
Number of Residues	5
Details	binding site for residue ZN A 2104

Chain	Residue
A	CYS1895
A	CYS1897
A	CYS1905
A	CYS1911
A	CYS1920

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	50
Details	Domain: {"description":"AWS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00562","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	117
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Domain: {"description":"Post-SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00155","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Region: {"description":"Inhibits enzyme activity in the absence of bound histone"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"21196496","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---