1XQH
Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
Summary for 1XQH
Entry DOI | 10.2210/pdb1xqh/pdb |
Related | 1h3i 1o9s |
Descriptor | Histone-lysine N-methyltransferase, H3 lysine-4 specific, 9-mer peptide from tumor protein p53, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total) |
Functional Keywords | set9-p53 complex, set-domain, lysine methylation, transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q8WTS6 Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 4 |
Total formula weight | 61726.69 |
Authors | Chuikov, S.,Kurash, J.K.,Wilson, J.R.,Xiao, B.,Justin, N.,Ivanov, G.S.,McKinney, K.,Tempst, P.,Prives, C.,Gamblin, S.J.,Barlev, N.A.,Reinberg, D. (deposition date: 2004-10-12, release date: 2004-11-23, Last modification date: 2023-10-25) |
Primary citation | Chuikov, S.,Kurash, J.K.,Wilson, J.R.,Xiao, B.,Justin, N.,Ivanov, G.S.,McKinney, K.,Tempst, P.,Prives, C.,Gamblin, S.J.,Barlev, N.A.,Reinberg, D. Regulation of p53 activity through lysine methylation Nature, 432:353-360, 2004 Cited by PubMed: 15525938DOI: 10.1038/nature03117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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