1XQH

Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, E)	Histone-lysine N-methyltransferase, H3 lysine-4 specific	polymer	264	29323.6	2	UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856)	Homo sapiens (human)	LYSINE N-METHYLTRANSFERASE, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain- containing Set7, Set9, SET7/9
2	B, D (B, F)	9-mer peptide from tumor protein p53	polymer	10	1155.3	2	UniProt (P04637)
3	E, F (A, E)	S-ADENOSYL-L-HOMOCYSTEINE	non-polymer		384.4	2	Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525)
4	G, H, I, J (A, B, E, F)	water	water		18.0	717	Chemie (HOH)

Sequence modifications

A, E: 108 - 366 (UniProt: Q8WTS6)

PDB	External Database	Details
Gly 103	-	cloning artifact
Pro 104	-	cloning artifact
Leu 105	-	cloning artifact
Gly 106	-	cloning artifact
Ser 107	-	cloning artifact

B, F: 369 - 377 (UniProt: P04637)

PDB	External Database	Details
Mlz 372	Lys 372	modified residue
Tyr 378	-	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	60957.9
Non-Polymers*	Number of molecules	2
	Total formula weight	768.8
All*	Total formula weight	61726.7

*Water molecules are not included.