1XQH
Crystal structure of a ternary complex of the methyltransferase SET9 (also known as SET7/9) with a P53 peptide and SAH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, E) | Histone-lysine N-methyltransferase, H3 lysine-4 specific | polymer | 264 | 29323.6 | 2 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (human) | LYSINE N-METHYLTRANSFERASE, Histone H3-K4 methyltransferase, H3-K4-HMTase, SET domain- containing Set7, Set9, SET7/9 |
| 2 | B, D (B, F) | 9-mer peptide from tumor protein p53 | polymer | 10 | 1155.3 | 2 | UniProt (P04637) | ||
| 3 | E, F (A, E) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | G, H, I, J (A, B, E, F) | water | water | 18.0 | 717 | Chemie (HOH) |
Sequence modifications
A, E: 108 - 366 (UniProt: Q8WTS6)
B, F: 369 - 377 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Gly 103 | - | cloning artifact |
| Pro 104 | - | cloning artifact |
| Leu 105 | - | cloning artifact |
| Gly 106 | - | cloning artifact |
| Ser 107 | - | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Mlz 372 | Lys 372 | modified residue |
| Tyr 378 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60957.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 768.8 | |
| All* | Total formula weight | 61726.7 |
