PDB: 76 件ウェブページステータス検索Chemie searchBIRD

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4JPY	Iron and phenylalanine bound crystal structure of phenylalanine hydroxylase from Chromobacterium violaceum 分子名称: FE (III) ION, PHENYLALANINE, Phenylalanine-4-hydroxylase 著者 Ronau, J.A, Abu-Omar, M.M, Das, C. 登録日 2013-03-19 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 An additional substrate binding site in a bacterial phenylalanine hydroxylase. Eur.Biophys.J., 42, 2013
6PAH	HUMAN PHENYLALANINE HYDROXYLASE CATALYTIC DOMAIN DIMER WITH BOUND L-DOPA (3,4-DIHYDROXYPHENYLALANINE) INHIBITOR 分子名称: 3,4-DIHYDROXYPHENYLALANINE, FE (III) ION, PHENYLALANINE 4-MONOOXYGENASE 著者 Erlandsen, H, Flatmark, T, Stevens, R.C. 登録日 1998-08-20 公開日 1999-04-27 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Crystallographic analysis of the human phenylalanine hydroxylase catalytic domain with bound catechol inhibitors at 2.0 A resolution. Biochemistry, 37, 1998
1PHZ	STRUCTURE OF PHOSPHORYLATED PHENYLALANINE HYDROXYLASE 分子名称: FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE) 著者 Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. 登録日 1998-11-11 公開日 1999-04-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural basis of autoregulation of phenylalanine hydroxylase. Nat.Struct.Biol., 6, 1999
1TG2	Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound 分子名称: 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, FE (III) ION, Phenylalanine-4-hydroxylase 著者 Erlandsen, H, Pey, A.L, Gamez, A, Perez, B, Desviat, L.R, Aguado, C, Koch, R, Surendran, S, Tyring, S, Matalon, R, Scriver, C.R, Ugarte, M, Martinez, A, Stevens, R.C. 登録日 2004-05-28 公開日 2004-11-30 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc.Natl.Acad.Sci.Usa, 101, 2004
7VGM	Crystal structure of Phenylalanine hydroxylase from Bacillus cereus ATCC 14579 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, DI(HYDROXYETHYL)ETHER, ... 著者 Park, J, Kim, K.-J. 登録日 2021-09-17 公開日 2022-04-27 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structural studies of a novel auxiliary-domain-containing phenylalanine hydroxylase from Bacillus cereus ATCC 14579. Acta Crystallogr D Struct Biol, 78, 2022
1TOH	TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT 分子名称: FE (III) ION, TYROSINE HYDROXYLASE 著者 Goodwill, K.E, Sabatier, C, Stevens, R.C. 登録日 1997-06-04 公開日 1998-06-03 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of tyrosine hydroxylase at 2.3 A and its implications for inherited neurodegenerative diseases. Nat.Struct.Biol., 4, 1997
2TOH	TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT 分子名称: 7,8-DIHYDROBIOPTERIN, CHLORIDE ION, FE (III) ION, ... 著者 Goodwill, K.E, Sabatier, C, Stevens, R.C. 登録日 1998-08-26 公開日 1999-08-26 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site. Biochemistry, 37, 1998
5JK8	Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex 分子名称: 7,8-DIHYDROBIOPTERIN, FE (III) ION, NORLEUCINE, ... 著者 Zhuang, N, Lee, K.H. 登録日 2016-04-26 公開日 2017-05-03 実験手法 X-RAY DIFFRACTION (2.394 Å) 主引用文献 Phenylalanine hydroxylase from dictyostelium - BH2, norleucine complex To Be Published
4BPT	Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila 分子名称: DI(HYDROXYETHYL)ETHER, PHENYLALANINE-4-HYDROXYLASE (PAH) (PHE-4-MONOOXYGENASE) 著者 Leiros, H.-K.S, Flydal, M.I, Martinez, A. 登録日 2013-05-28 公開日 2013-08-21 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural and Thermodynamic Insight Into Phenylalanine Hydroxylase from the Human Pathogen Legionella Pneumophila. FEBS Open Bio, 3, 2013
1KW0	Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, BETA(2-THIENYL)ALANINE, FE (II) ION, ... 著者 Andersen, O.A, Flatmark, T, Hough, E. 登録日 2002-01-28 公開日 2003-01-28 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation J.Mol.Biol., 320, 2002
5EGQ	Structure of tetrameric rat phenylalanine hydroxylase mutant R270K, residues 25-453 分子名称: Phenylalanine-4-hydroxylase, SULFATE ION 著者 Taylor, A.B, Khan, C.A, Fitzpatrick, P.F. 登録日 2015-10-27 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering. J.Am.Chem.Soc., 138, 2016
7ZIK	Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401 分子名称: (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, FE (III) ION, Tryptophan 5-hydroxylase 1 著者 Schuetz, A, Heinemann, U. 登録日 2022-04-08 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.58925915 Å) 主引用文献 Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors. J.Med.Chem., 65, 2022
2PHM	STRUCTURE OF PHENYLALANINE HYDROXYLASE DEPHOSPHORYLATED 分子名称: FE (III) ION, PROTEIN (PHENYLALANINE-4-HYDROXYLASE) 著者 Kobe, B, Jennings, I.G, House, C.M, Michell, B.J, Cotton, R.G, Kemp, B.E. 登録日 1998-11-11 公開日 1999-04-30 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural basis of autoregulation of phenylalanine hydroxylase. Nat.Struct.Biol., 6, 1999
4V06	Crystal structure of human tryptophan hydroxylase 2 (TPH2), catalytic domain 分子名称: FE (III) ION, IMIDAZOLE, TRYPTOPHAN 5-HYDROXYLASE 2 著者 Kopec, J, Oberholzer, A, Fitzpatrick, F, Newman, J, Tallant, C, Kiyani, W, Shrestha, L, Burgess-Brown, N, von Delft, F, Arrowsmith, C, Edwards, A, Bountra, C, Yue, W.W. 登録日 2014-09-11 公開日 2014-10-15 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.63 Å) 主引用文献 Crystal Structure of Human Tryptophane Hydroxylase 2 (Tph2), Catalytic Domain To be Published
2XSN	Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain 分子名称: TYROSINE 3-MONOOXYGENASE, ZINC ION 著者 Muniz, J.R.C, Cooper, C.D.O, Yue, W.W, Krysztofinska, E, von Delft, F, Knapp, S, Gileadi, O, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Kavanagh, K.L, Oppermann, U. 登録日 2010-10-29 公開日 2010-11-17 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Crystal Structure of Human Tyrosine Hydroxylase Catalytic Domain To be Published
5DEN	The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer 分子名称: FE (III) ION, Phenylalanine-4-hydroxylase 著者 Arturo, E.C, Loll, P.J, Jaffe, E.K. 登録日 2015-08-25 公開日 2016-02-17 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc.Natl.Acad.Sci.USA, 113, 2016
6N1K	Full-length human phenylalanine hydroxylase (PAH) in the resting state 分子名称: CHLORIDE ION, FE (III) ION, Phenylalanine-4-hydroxylase 著者 Arturo, E.C, Jaffe, E.K. 登録日 2018-11-08 公開日 2019-05-22 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.057 Å) 主引用文献 Biophysical characterization of full-length human phenylalanine hydroxylase provides a deeper understanding of its quaternary structure equilibrium. J.Biol.Chem., 294, 2019
7WIY	Cryo-EM structure of human TPH2 tetramer 分子名称: FE (III) ION, IMIDAZOLE, Tryptophan 5-hydroxylase 2 著者 Zhu, K.F, Liu, C, Zhang, H.W, Wang, D.P. 登録日 2022-01-05 公開日 2022-10-05 実験手法 ELECTRON MICROSCOPY (3.09 Å) 主引用文献 Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. Front Pharmacol, 13, 2022
2PAH	TETRAMERIC HUMAN PHENYLALANINE HYDROXYLASE 分子名称: FE (III) ION, PROTEIN (PHENYLALANINE HYDROXYLASE) 著者 Stevens, R.C, Fusetti, F, Erlandsen, H. 登録日 1998-05-26 公開日 1999-10-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria. J.Biol.Chem., 273, 1998
6HYC	The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin 分子名称: 5,6,7,8-TETRAHYDROBIOPTERIN, Phenylalanine-4-hydroxylase 著者 Alcorlo Pages, M, Flydal, I.M. 登録日 2018-10-19 公開日 2019-06-05 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.18 Å) 主引用文献 Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Proc.Natl.Acad.Sci.USA, 116, 2019
6ZZU	Partial structure of the substrate-free tyrosine hydroxylase (apo-TH). 分子名称: FE (III) ION, Tyrosine 3-monooxygenase 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. 登録日 2020-08-05 公開日 2021-11-17 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
5FGJ	Structure of tetrameric rat phenylalanine hydroxylase, residues 1-453 分子名称: FE (III) ION, MAGNESIUM ION, Phenylalanine-4-hydroxylase 著者 Taylor, A.B, Roberts, K.M, Fitzpatrick, P.F. 登録日 2015-12-20 公開日 2016-05-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.6 Å) 主引用文献 Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering. J.Am.Chem.Soc., 138, 2016
6ZVP	Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms 分子名称: FE (III) ION, L-DOPAMINE, Tyrosine 3-monooxygenase 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. 登録日 2020-07-27 公開日 2021-11-17 最終更新日 2022-02-02 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
7A2G	Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH). 分子名称: FE (III) ION, Tyrosine 3-monooxygenase 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Flydal, M.I, Martinez, A, Valpuesta, J.M. 登録日 2020-08-17 公開日 2021-12-01 最終更新日 2022-06-22 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022
6ZN2	Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding. 分子名称: FE (III) ION, L-DOPAMINE, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, ... 著者 Bueno-Carrasco, M.T, Cuellar, J, Santiago, C, Valpuesta, J.M, Martinez, A, Flydal, M.I. 登録日 2020-07-06 公開日 2021-12-08 最終更新日 2022-02-02 実験手法 ELECTRON MICROSCOPY (4.3 Å) 主引用文献 Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13, 2022

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