1TG2

Crystal structure of phenylalanine hydroxylase A313T mutant with 7,8-dihydrobiopterin bound

Summary for 1TG2

Entry DOI	10.2210/pdb1tg2/pdb
Related	1LRM 1PAH 1TDW
Descriptor	Phenylalanine-4-hydroxylase, FE (III) ION, 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, ... (4 entities in total)
Functional Keywords	phenylalanine hydroxylase phenylketonuria mutant a313t in complex with cofactor analogue 7, 8-dihydrobiopterin, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	36025.62
Authors	Erlandsen, H.,Pey, A.L.,Gamez, A.,Perez, B.,Desviat, L.R.,Aguado, C.,Koch, R.,Surendran, S.,Tyring, S.,Matalon, R.,Scriver, C.R.,Ugarte, M.,Martinez, A.,Stevens, R.C. (deposition date: 2004-05-28, release date: 2004-11-30, Last modification date: 2023-08-23)
Primary citation	Erlandsen, H.,Pey, A.L.,Gamez, A.,Perez, B.,Desviat, L.R.,Aguado, C.,Koch, R.,Surendran, S.,Tyring, S.,Matalon, R.,Scriver, C.R.,Ugarte, M.,Martinez, A.,Stevens, R.C. Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations. Proc.Natl.Acad.Sci.Usa, 101:16903-16908, 2004 Cited by PubMed: 15557004 DOI: 10.1073/pnas.0407256101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation