7ZIK

Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401

Summary for 7ZIK

• Entry DOI: 10.2210/pdb7zik/pdb
• Descriptor: Tryptophan 5-hydroxylase 1, FE (III) ION, (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid, ... (4 entities in total)
• Functional Keywords: tryptophan hydroxylase, serotonin biosynthesis, metal binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 76054.75

Authors

Schuetz, A.,Heinemann, U. (deposition date: 2022-04-08, release date: 2022-09-07, Last modification date: 2024-01-31)

• Primary citation: Specker, E.,Matthes, S.,Wesolowski, R.,Schutz, A.,Grohmann, M.,Alenina, N.,Pleimes, D.,Mallow, K.,Neuenschwander, M.,Gogolin, A.,Weise, M.,Pfeifer, J.,Ziebart, N.,Heinemann, U.,von Kries, J.P.,Nazare, M.,Bader, M.; Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.; J.Med.Chem., 65:11126-11149, 2022; PubMed: 35921615; DOI: 10.1021/acs.jmedchem.2c00598

Experimental method

X-RAY DIFFRACTION (2.58925907124 Å)