7ZIK
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tryptophan 5-hydroxylase 1 | polymer | 326 | 37424.6 | 2 | UniProt (P17752) Pfam (PF00351) In PDB | Homo sapiens (human) | Tryptophan 5-monooxygenase 1 |
2 | A, B | FE (III) ION | non-polymer | 55.8 | 2 | Chemie (FE) | |||
3 | A, B | (2~{R})-2-azanyl-3-[4-[2-azanyl-6-[(1~{R})-1-[4-chloranyl-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-tris(fluoranyl)ethoxy]pyrimidin-4-yl]phenyl]propanoic acid | non-polymer | 546.9 | 2 | Chemie (IVN) | |||
4 | water | water | 18.0 | 76 | Chemie (HOH) |
Sequence modifications
A, B: 105 - 401 (UniProt: P17752)
PDB | External Database | Details |
---|---|---|
Met 76 | - | initiating methionine |
Lys 77 | - | expression tag |
His 78 | - | expression tag |
His 79 | - | expression tag |
His 80 | - | expression tag |
His 81 | - | expression tag |
His 82 | - | expression tag |
His 83 | - | expression tag |
His 84 | - | expression tag |
Gly 85 | - | expression tag |
Ala 86 | - | expression tag |
Ala 87 | - | expression tag |
Gly 88 | - | expression tag |
Thr 89 | - | expression tag |
Ser 90 | - | expression tag |
Leu 91 | - | expression tag |
Tyr 92 | - | expression tag |
Lys 93 | - | expression tag |
Lys 94 | - | expression tag |
Ala 95 | - | expression tag |
Gly 96 | - | expression tag |
Glu 97 | - | expression tag |
Asn 98 | - | expression tag |
Leu 99 | - | expression tag |
Tyr 100 | - | expression tag |
Phe 101 | - | expression tag |
Gln 102 | - | expression tag |
Gly 103 | - | expression tag |
Ser 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 74849.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1205.5 | |
All* | Total formula weight | 76054.8 |