7ZIK
Crystal structure of human tryptophan hydroxylase 1 in complex with inhibitor LP533401
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0009072 | biological_process | aromatic amino acid metabolic process |
A | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0005506 | molecular_function | iron ion binding |
B | 0009072 | biological_process | aromatic amino acid metabolic process |
B | 0016714 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen |
Functional Information from PROSITE/UniProt
site_id | PS00367 |
Number of Residues | 12 |
Details | BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDtcHELLGHVP |
Chain | Residue | Details |
A | PRO268-PRO279 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P70080 |
Chain | Residue | Details |
A | TYR235 | |
B | ILE366 | |
A | ARG257 | |
A | THR265 | |
A | SER336 | |
A | ILE366 | |
B | TYR235 | |
B | ARG257 | |
B | THR265 | |
B | SER336 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000269|PubMed:12379098, ECO:0007744|PDB:1MLW |
Chain | Residue | Details |
A | HIS272 | |
A | HIS277 | |
A | GLU317 | |
B | HIS272 | |
B | HIS277 | |
B | GLU317 |