6ZN2
Partial structure of tyrosine hydroxylase in complex with dopamine showing the catalytic domain and an alpha-helix from the regulatory domain involved in dopamine binding.
Summary for 6ZN2
Entry DOI | 10.2210/pdb6zn2/pdb |
EMDB information | 11309 |
Descriptor | Tyrosine 3-monooxygenase, SER-LEU-ILE-GLU-ASP-ALA-ARG-LYS-GLU-ARG-GLU-ALA-ALA-VAL-ALA-ALA-ALA-ALA, L-DOPAMINE, ... (4 entities in total) |
Functional Keywords | tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 160683.48 |
Authors | Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (deposition date: 2020-07-06, release date: 2021-12-08, Last modification date: 2024-07-10) |
Primary citation | Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13:74-74, 2022 Cited by PubMed: 35013193DOI: 10.1038/s41467-021-27657-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.3 Å) |
Structure validation
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