1KW0

Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine

Summary for 1KW0

Entry DOI	10.2210/pdb1kw0/pdb
Related	1DMW 1J8T 1J8U 1PAH 2PAH
Descriptor	Phenylalanine-4-hydroxylase, FE (II) ION, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total)
Functional Keywords	basket-arrangement 13 alpha-helices and 6 beta-strands, ferrous iron, oxidoreductase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38069.88
Authors	Andersen, O.A.,Flatmark, T.,Hough, E. (deposition date: 2002-01-28, release date: 2003-01-28, Last modification date: 2023-08-16)
Primary citation	Andersen, O.A.,Flatmark, T.,Hough, E. Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation J.Mol.Biol., 320:1095-1108, 2002 Cited by PubMed: 12126628 DOI: 10.1016/S0022-2836(02)00560-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation