7A2G
Full-length structure of the substrate-free tyrosine hydroxylase (apo-TH).
Summary for 7A2G
| Entry DOI | 10.2210/pdb7a2g/pdb |
| EMDB information | 11309 11467 11587 11624 |
| Descriptor | Tyrosine 3-monooxygenase, FE (III) ION (3 entities in total) |
| Functional Keywords | tetramer, catecholamine, brain, parkinson, oxidoreductase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 190125.77 |
| Authors | Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Flydal, M.I.,Martinez, A.,Valpuesta, J.M. (deposition date: 2020-08-17, release date: 2021-12-01, Last modification date: 2022-06-22) |
| Primary citation | Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13:74-74, 2022 Cited by PubMed: 35013193DOI: 10.1038/s41467-021-27657-y PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
Download full validation report
