6ZVP

Atomic model of the EM-based structure of the full-length tyrosine hydroxylase in complex with dopamine (residues 40-497) in which the regulatory domain (residues 40-165) has been included only with the backbone atoms

Summary for 6ZVP

Entry DOI	10.2210/pdb6zvp/pdb
EMDB information	11309 11467
Descriptor	Tyrosine 3-monooxygenase, FE (III) ION, L-DOPAMINE (3 entities in total)
Functional Keywords	tetramer, dopamine, catecholamine, brain, parkinson, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	206435.53
Authors	Bueno-Carrasco, M.T.,Cuellar, J.,Santiago, C.,Valpuesta, J.M.,Martinez, A.,Flydal, M.I. (deposition date: 2020-07-27, release date: 2021-11-17, Last modification date: 2022-02-02)
Primary citation	Bueno-Carrasco, M.T.,Cuellar, J.,Flydal, M.I.,Santiago, C.,Krakenes, T.A.,Kleppe, R.,Lopez-Blanco, J.R.,Marcilla, M.,Teigen, K.,Alvira, S.,Chacon, P.,Martinez, A.,Valpuesta, J.M. Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation. Nat Commun, 13:74-74, 2022 Cited by PubMed: 35013193 DOI: 10.1038/s41467-021-27657-y PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4 Å)

Structure validation