6HYC

The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin

Summary for 6HYC

Entry DOI	10.2210/pdb6hyc/pdb
Descriptor	Phenylalanine-4-hydroxylase, 5,6,7,8-TETRAHYDROBIOPTERIN (3 entities in total)
Functional Keywords	tetrahydrobiopterin, phenylalanine hydroxylase, phenylketonuria, allostery, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	208439.37
Authors	Alcorlo Pages, M.,Flydal, I.M. (deposition date: 2018-10-19, release date: 2019-06-05, Last modification date: 2024-01-24)
Primary citation	Flydal, M.I.,Alcorlo-Pages, M.,Johannessen, F.G.,Martinez-Caballero, S.,Skjærven, L.,Fernandez-Leiro, R.,Martinez, A.,Hermoso, J.A. Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin. Proc.Natl.Acad.Sci.USA, 116:11229-11234, 2019 Cited by PubMed: 31118288 DOI: 10.1073/pnas.1902639116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.18 Å)

Structure validation