6HYC

The structure of full-length human phenylalanine hydroxylase in complex with the cofactor and negative regulator tetrahydrobiopterin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005829	cellular_component	cytosol
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006571	biological_process	L-tyrosine biosynthetic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
A	0042423	biological_process	catecholamine biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004497	molecular_function	monooxygenase activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005829	cellular_component	cytosol
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006571	biological_process	L-tyrosine biosynthetic process
B	0008652	biological_process	amino acid biosynthetic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
B	0042423	biological_process	catecholamine biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004497	molecular_function	monooxygenase activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0005829	cellular_component	cytosol
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006571	biological_process	L-tyrosine biosynthetic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
C	0042423	biological_process	catecholamine biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004497	molecular_function	monooxygenase activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0005829	cellular_component	cytosol
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006571	biological_process	L-tyrosine biosynthetic process
D	0008652	biological_process	amino acid biosynthetic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
D	0042423	biological_process	catecholamine biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue H4B D 501

Chain	Residue
D	SER23
D	GLY247
D	LEU248
D	LEU249
D	SER251
D	PHE254
D	LEU255
D	TYR325

---

site_id	AC2
Number of Residues	9
Details	binding site for residue H4B C 501

Chain	Residue
C	ILE25
C	GLY247
C	LEU248
C	LEU249
C	SER251
C	PHE254
C	ALA322
C	TYR325
C	SER23

---

site_id	AC3
Number of Residues	9
Details	binding site for residue H4B B 501

Chain	Residue
B	SER23
B	VAL245
B	GLY247
B	LEU248
B	LEU249
B	SER251
B	PHE254
B	ALA322
B	TYR325

---

Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDicHELLGHVP

Chain	Residue	Details
D	PRO281-PRO292

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"ACT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P04176","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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