5DEN

The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer

Summary for 5DEN

Entry DOI	10.2210/pdb5den/pdb
Descriptor	Phenylalanine-4-hydroxylase, FE (III) ION (3 entities in total)
Functional Keywords	mammalian phenylalanine hydroxylase, allosteric regulation by phenylalanine, phenylketonuria, act-containing, oxidoreductase
Biological source	Rattus norvegicus (Rat)
Total number of polymer chains	4
Total formula weight	207709.62
Authors	Arturo, E.C.,Loll, P.J.,Jaffe, E.K. (deposition date: 2015-08-25, release date: 2016-02-17, Last modification date: 2023-09-27)
Primary citation	Arturo, E.C.,Gupta, K.,Heroux, A.,Stith, L.,Cross, P.J.,Parker, E.J.,Loll, P.J.,Jaffe, E.K. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc.Natl.Acad.Sci.USA, 113:2394-2399, 2016 Cited by PubMed: 26884182 DOI: 10.1073/pnas.1516967113 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation