5DEN
The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer
Summary for 5DEN
Entry DOI | 10.2210/pdb5den/pdb |
Descriptor | Phenylalanine-4-hydroxylase, FE (III) ION (3 entities in total) |
Functional Keywords | mammalian phenylalanine hydroxylase, allosteric regulation by phenylalanine, phenylketonuria, act-containing, oxidoreductase |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 4 |
Total formula weight | 207709.62 |
Authors | Arturo, E.C.,Loll, P.J.,Jaffe, E.K. (deposition date: 2015-08-25, release date: 2016-02-17, Last modification date: 2023-09-27) |
Primary citation | Arturo, E.C.,Gupta, K.,Heroux, A.,Stith, L.,Cross, P.J.,Parker, E.J.,Loll, P.J.,Jaffe, E.K. First structure of full-length mammalian phenylalanine hydroxylase reveals the architecture of an autoinhibited tetramer. Proc.Natl.Acad.Sci.USA, 113:2394-2399, 2016 Cited by PubMed: 26884182DOI: 10.1073/pnas.1516967113 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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