5DEN

The First Structure of a Full-Length Mammalian Phenylalanine Hydroxylase Reveals the Architecture of an Auto-inhibited Tetramer

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004497	molecular_function	monooxygenase activity
A	0004505	molecular_function	phenylalanine 4-monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0006558	biological_process	L-phenylalanine metabolic process
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006571	biological_process	L-tyrosine biosynthetic process
A	0009072	biological_process	aromatic amino acid metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016597	molecular_function	amino acid binding
A	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
A	0018126	biological_process	protein hydroxylation
A	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004497	molecular_function	monooxygenase activity
B	0004505	molecular_function	phenylalanine 4-monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0006558	biological_process	L-phenylalanine metabolic process
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006571	biological_process	L-tyrosine biosynthetic process
B	0009072	biological_process	aromatic amino acid metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016597	molecular_function	amino acid binding
B	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
B	0018126	biological_process	protein hydroxylation
B	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004497	molecular_function	monooxygenase activity
C	0004505	molecular_function	phenylalanine 4-monooxygenase activity
C	0005506	molecular_function	iron ion binding
C	0006558	biological_process	L-phenylalanine metabolic process
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006571	biological_process	L-tyrosine biosynthetic process
C	0009072	biological_process	aromatic amino acid metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016597	molecular_function	amino acid binding
C	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
C	0018126	biological_process	protein hydroxylation
C	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004497	molecular_function	monooxygenase activity
D	0004505	molecular_function	phenylalanine 4-monooxygenase activity
D	0005506	molecular_function	iron ion binding
D	0006558	biological_process	L-phenylalanine metabolic process
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006571	biological_process	L-tyrosine biosynthetic process
D	0009072	biological_process	aromatic amino acid metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016597	molecular_function	amino acid binding
D	0016714	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
D	0018126	biological_process	protein hydroxylation
D	0019293	biological_process	L-tyrosine biosynthetic process, by oxidation of phenylalanine
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue FE A 501

Chain	Residue
A	HIS285
A	HIS290
A	GLU330
A	HOH601
A	HOH602

---

site_id	AC2
Number of Residues	6
Details	binding site for residue FE B 501

Chain	Residue
B	HOH601
B	HOH602
B	HIS285
B	HIS290
B	TYR325
B	GLU330

---

site_id	AC3
Number of Residues	5
Details	binding site for residue FE C 501

Chain	Residue
C	HIS285
C	HIS290
C	GLU330
C	HOH601
C	HOH602

---

site_id	AC4
Number of Residues	5
Details	binding site for residue FE D 501

Chain	Residue
D	HIS285
D	HIS290
D	GLU330
D	HOH601
D	HOH602

---

Functional Information from PROSITE/UniProt

site_id	PS00367
Number of Residues	12
Details	BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDicHELLGHVP

Chain	Residue	Details
A	PRO281-PRO292

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	312
Details	Domain: {"description":"ACT","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10331871","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PHZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PHM","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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