PDB: 346 件ウェブページステータス検索Chemie searchBIRD

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2H44	Crystal structure of PDE5A1 in complex with icarisid II 分子名称: 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ... 著者 Wang, H, Ke, H. 登録日 2006-05-23 公開日 2006-06-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
2H40	Crystal structure of the catalytic domain of unliganded PDE5 分子名称: MAGNESIUM ION, ZINC ION, cGMP-specific 3',5'-cyclic phosphodiesterase 著者 Wang, H, Liu, Y, Huai, Q, Cai, J, Zoraghi, R, Francis, S.H, Corbin, J.D, Robinson, H, Xin, Z, Lin, G, Ke, H. 登録日 2006-05-23 公開日 2006-06-06 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281, 2006
2HD1	Crystal structure of PDE9 in complex with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ... 著者 Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H. 登録日 2006-06-19 公開日 2006-06-27 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding Proc.Natl.Acad.Sci.USA, 101, 2004
2O8H	Crystal structure of the catalytic domain of rat phosphodiesterase 10A 分子名称: 6,7-DIMETHOXY-4-{8-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]-3,4-DIHYDROISOQUINOLIN-2(1H)-YL}QUINAZOLINE, MAGNESIUM ION, Phosphodiesterase-10A, ... 著者 Pandit, J, Marr, E.S. 登録日 2006-12-12 公開日 2007-01-09 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors J.Med.Chem., 50, 2007
2OVY	Crystal structure of the catalytic domain of rat phosphodiesterase 10A 分子名称: 6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE, MAGNESIUM ION, Phosphodiesterase-10A, ... 著者 Pandit, J, Marr, E.S. 登録日 2007-02-15 公開日 2007-03-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors J.Med.Chem., 50, 2007
2OVV	Crystal structure of the catalytic domain of rat phosphodiesterase 10A 分子名称: 6,7-DIMETHOXY-4-[(3R)-3-(2-NAPHTHYLOXY)PYRROLIDIN-1-YL]QUINAZOLINE, MAGNESIUM ION, Phosphodiesterase-10A, ... 著者 Pandit, J, Marr, E.S. 登録日 2007-02-15 公開日 2007-03-06 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors J.Med.Chem., 50, 2007
2YY2	Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High-affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... 著者 Handa, N, Shirouzu, M, Terada, T, Omori, K, Kotera, J, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2007-04-27 公開日 2007-10-30 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of the human Phosphodiesterase 9A catalytic domain To be Published
2PW3	Structure of the PDE4D-cAMP complex 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D 著者 Wang, H, Robinson, H, Ke, H. 登録日 2007-05-10 公開日 2007-10-23 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 The molecular basis for different recognition of substrates by phosphodiesterase families 4 and 10. J.Mol.Biol., 371, 2007
2QYM	crystal structure of unliganded PDE4C2 分子名称: MAGNESIUM ION, Phosphodiesterase 4C, ZINC ION 著者 Ke, H. 登録日 2007-08-15 公開日 2008-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
2QYK	Crystal structure of PDE4A10 in complex with inhibitor NPV 分子名称: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, Cyclic AMP-specific phosphodiesterase HSPDE4A10, MAGNESIUM ION, ... 著者 Wang, H, Peng, M, Chen, Y, Geng, J, Robinson, H, Houslay, M. 登録日 2007-08-15 公開日 2008-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
2QYN	Crystal structure of PDE4D2 in complex with inhibitor NPV 分子名称: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, ZINC ION, ... 著者 Ke, H. 登録日 2007-08-15 公開日 2008-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
2QYL	Crystal structure of PDE4B2B in complex with inhibitor NPV 分子名称: 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid, MAGNESIUM ION, Phosphodiesterase 4B, ... 著者 Ke, H. 登録日 2007-08-15 公開日 2008-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors. Biochem.J., 408, 2007
2R8Q	Structure of LmjPDEB1 in complex with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, Class I phosphodiesterase PDEB1, MAGNESIUM ION, ... 著者 Wang, H, Yan, Z, Geng, J, Kunz, S, Seebeck, T, Ke, H. 登録日 2007-09-11 公開日 2007-12-18 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol.Microbiol., 66, 2007
3B2R	Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil 分子名称: 2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN-4(1H)-ONE, cGMP-specific 3',5'-cyclic phosphodiesterase 著者 Huanchen, W, Mengchun, Y, Howard, R, Sharron, H.F, Hengming, K. 登録日 2007-10-19 公開日 2008-05-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Conformational variations of both phosphodiesterase-5 and inhibitors provide the structural basis for the physiological effects of vardenafil and sildenafil. Mol.Pharmacol., 73, 2008
3BJC	Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor 分子名称: 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide, MAGNESIUM ION, ZINC ION, ... 著者 Chen, G, Wang, H, Howard, R, Cai, J, Wan, Y, Ke, H. 登録日 2007-12-03 公開日 2008-04-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM., 75, 2008
2ZMF	Crystal structure of the C-terminal GAF domain of human phosphodiesterase 10A 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 著者 Handa, N, Kishishita, S, Mizohata, E, Omori, K, Kotera, J, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2008-04-17 公開日 2008-04-29 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP J.Biol.Chem., 283, 2008
3D3P	Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor 分子名称: 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide, ARSENIC, MAGNESIUM ION, ... 著者 Somers, D.O, Neu, M. 登録日 2008-05-12 公開日 2009-05-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors. Bioorg.Med.Chem.Lett., 18, 2008
3DY8	Human Phosphodiesterase 9 in complex with product 5'-GMP (E+P complex) 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, FORMIC ACID, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Liu, S, Mansour, M.N, Dillman, K, Perez, J, Danley, D, Menniti, F. 登録日 2008-07-25 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DYL	human phosphdiesterase 9 substrate complex (ES complex) 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, CYCLIC GUANOSINE MONOPHOSPHATE, FORMIC ACID, ... 著者 Liu, S, Mansour, M.N, Dillman, K, Perez, J, Danley, D, Menniti, F. 登録日 2008-07-28 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DYQ	human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, CYCLIC GUANOSINE MONOPHOSPHATE, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... 著者 Liu, S, Mansour, M.N, Dillman, K, Perez, J, Danley, D, Menniti, F. 登録日 2008-07-28 公開日 2008-09-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DYN	human phosphodiestrase 9 in complex with cGMP (Zn inhibited) 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, CYCLIC GUANOSINE MONOPHOSPHATE, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ... 著者 Liu, S, Mansour, M.N, Dillman, K, Perez, J, Danley, D, Menniti, F. 登録日 2008-07-28 公開日 2008-09-16 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105, 2008
3DYS	human phosphodiestrase-5'GMP complex (EP), produced by soaking with 20mM cGMP+20 mM MnCl2+20 mM MgCl2 for 2 hours, and flash-cooled to liquid nitrogen temperature when substrate was still abudant. 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, FORMIC ACID, GUANOSINE-5'-MONOPHOSPHATE, ... 著者 Liu, S, Mansour, M.N, Dillman, K, Perez, J, Danley, D, Menniti, F. 登録日 2008-07-28 公開日 2008-09-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105, 2008
3ECN	Crystal structure of PDE8A catalytic domain in complex with IBMX 分子名称: 3-ISOBUTYL-1-METHYLXANTHINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... 著者 Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H. 登録日 2008-09-01 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47, 2008
3ECM	Crystal structure of the unliganded PDE8A catalytic domain 分子名称: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ZINC ION 著者 Wang, H, Yan, Z, Yang, S, Cai, J, Robinson, H, Ke, H. 登録日 2008-09-01 公開日 2008-11-25 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47, 2008
3FRG	Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor 分子名称: 4-[(3-methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide, ARSENIC, GLYCEROL, ... 著者 Somers, D.O, Neu, M. 登録日 2009-01-08 公開日 2010-01-12 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration. Bioorg.Med.Chem.Lett., 19, 2009

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