3BJC
Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor
Summary for 3BJC
Entry DOI | 10.2210/pdb3bjc/pdb |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | pde5, erectile dysfunction, inhibitor design, allosteric enzyme, alternative splicing, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphoprotein, polymorphism, zinc |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 100907.33 |
Authors | |
Primary citation | Chen, G.,Wang, H.,Robinson, H.,Cai, J.,Wan, Y.,Ke, H. An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies BIOCHEM.PHARM., 75:1717-1728, 2008 Cited by PubMed: 18346713DOI: 10.1016/j.bcp.2008.01.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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