3BJC
Crystal structure of the PDE5A catalytic domain in complex with a novel inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 878 | 100420.1 | 1 | UniProt (O76074) Pfam (PF01590) Pfam (PF00233) | Homo sapiens (human) | CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide | non-polymer | 397.5 | 1 | Chemie (WAN) | |||
| 5 | E (A) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 1 - 875 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 100420.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 487.2 | |
| All* | Total formula weight | 100907.3 |
