3ECM
Crystal structure of the unliganded PDE8A catalytic domain
Summary for 3ECM
Entry DOI | 10.2210/pdb3ecm/pdb |
Related | 3ECN |
Descriptor | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, ZINC ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | phosphodiesterase 8a pde8a inhibitor selectivity, alternative splicing, camp, hydrolase, magnesium, manganese, metal-binding |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 39179.73 |
Authors | |
Primary citation | Wang, H.,Yan, Z.,Yang, S.,Cai, J.,Robinson, H.,Ke, H. Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity Biochemistry, 47:12760-12768, 2008 Cited by PubMed: 18983167DOI: 10.1021/bi801487x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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