2OVY

Crystal structure of the catalytic domain of rat phosphodiesterase 10A

Summary for 2OVY

• Entry DOI: 10.2210/pdb2ovy/pdb
• Related: 2O8H 2OVV
• Descriptor: Phosphodiesterase-10A, SULFATE ION, ZINC ION, ... (6 entities in total)
• Functional Keywords: phosphodiesterase 10a; zn-binding site, hydrolase
• Biological source: Rattus norvegicus (Norway rat)
• Cellular location: Cytoplasm : Q9QYJ6
• Total number of polymer chains: 1
• Total formula weight: 42250.93

Authors

Pandit, J.,Marr, E.S. (deposition date: 2007-02-15, release date: 2007-03-06, Last modification date: 2024-02-21)

• Primary citation: Chappie, T.A.,Humphrey, J.M.,Allen, M.P.,Estep, K.G.,Fox, C.B.,Lebel, L.A.,Liras, S.,Marr, E.S.,Menniti, F.S.,Pandit, J.,Schmidt, C.J.,Tu, M.,Williams, R.D.,Yang, F.V.; Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors; J.Med.Chem., 50:182-185, 2007; PubMed: 17228859; DOI: 10.1021/jm060653b

Experimental method

X-RAY DIFFRACTION (1.8 Å)