2OVY

Crystal structure of the catalytic domain of rat phosphodiesterase 10A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Phosphodiesterase-10A	polymer	362	41661.7	1	UniProt (Q9QYJ6) Pfam (PF00233) In PDB	Rattus norvegicus (Norway rat)	PDE10A2
2	A	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
3	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
4	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
5	A	6,7-DIMETHOXY-4-[(3R)-3-(QUINOXALIN-2-YLOXY)PYRROLIDIN-1-YL]QUINAZOLINE	non-polymer		403.4	1	Chemie (PFJ)
6		water	water		18.0	334	Chemie (HOH)

Sequence modifications

A: 442 - 784 (UniProt: Q9QYJ6)

PDB	External Database	Details
Met 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
Ser 430	-	expression tag
Ser 431	-	expression tag
Gly 432	-	expression tag
Leu 433	-	expression tag
Val 434	-	expression tag
Pro 435	-	expression tag
Arg 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag
Ala 439	-	expression tag
Met 440	-	expression tag
Gly 441	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	41661.7
Non-Polymers*	Number of molecules	4
	Total formula weight	589.2
All*	Total formula weight	42250.9

*Water molecules are not included.