2QYL

Crystal structure of PDE4B2B in complex with inhibitor NPV

Summary for 2QYL

• Entry DOI: 10.2210/pdb2qyl/pdb
• Related: 2qyk 2qym 2qyn
• Descriptor: Phosphodiesterase 4B, cAMP-specific, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde4b structure, selective inhibitor nvp, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 39334.35

Authors

Ke, H. (deposition date: 2007-08-15, release date: 2008-04-08, Last modification date: 2024-04-03)

• Primary citation: Wang, H.,Peng, M.S.,Chen, Y.,Geng, J.,Robinson, H.,Houslay, M.D.,Cai, J.,Ke, H.; Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.; Biochem.J., 408:193-201, 2007; PubMed: 17727341; DOI: 10.1042/BJ20070970

Experimental method

X-RAY DIFFRACTION (1.95 Å)