3FRG

Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor

Summary for 3FRG

Entry DOI	10.2210/pdb3frg/pdb
Related	1F0J
Descriptor	cAMP-specific 3',5'-cyclic phosphodiesterase 4B, 4-[(3-methoxyphenyl)amino]-6-(methylsulfonyl)quinoline-3-carboxamide, ZINC ION, ... (7 entities in total)
Functional Keywords	pde, phosphodiesterase, camp, alternative splicing, hydrolase, phosphoprotein, polymorphism, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	41454.03
Authors	Somers, D.O.,Neu, M. (deposition date: 2009-01-08, release date: 2010-01-12, Last modification date: 2023-09-06)
Primary citation	Lunniss, C.J.,Cooper, A.W.,Eldred, C.D.,Kranz, M.,Lindvall, M.,Lucas, F.S.,Neu, M.,Preston, A.G.,Ranshaw, L.E.,Redgrave, A.J.,Ed Robinson, J.,Shipley, T.J.,Solanke, Y.E.,Somers, D.O.,Wiseman, J.O. Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration. Bioorg.Med.Chem.Lett., 19:1380-1385, 2009 Cited by PubMed: 19195882 DOI: 10.1016/j.bmcl.2009.01.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation