3DYN
human phosphodiestrase 9 in complex with cGMP (Zn inhibited)
Summary for 3DYN
Entry DOI | 10.2210/pdb3dyn/pdb |
Related | 3DY8 3DYL 3DYQ 3DYS |
Descriptor | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | phophodiestrase, enzyme mechanism, cgmp, hydrolase, manganese, metal-binding, phosphoprotein |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform PDE9A1: Cell projection, ruffle membrane. Isoform PDE9A2: Cell projection, ruffle membrane. Isoform PDE9A3: Cytoplasm. Isoform PDE9A17: Cytoplasm: O76083 |
Total number of polymer chains | 2 |
Total formula weight | 78817.93 |
Authors | Liu, S.,Mansour, M.N.,Dillman, K.,Perez, J.,Danley, D.,Menniti, F. (deposition date: 2008-07-28, release date: 2008-09-16, Last modification date: 2023-08-30) |
Primary citation | Liu, S.,Mansour, M.N.,Dillman, K.S.,Perez, J.R.,Danley, D.E.,Aeed, P.A.,Simons, S.P.,Lemotte, P.K.,Menniti, F.S. Structural basis for the catalytic mechanism of human phosphodiesterase 9. Proc.Natl.Acad.Sci.Usa, 105:13309-13314, 2008 Cited by PubMed: 18757755DOI: 10.1073/pnas.0708850105 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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