2H40

Crystal structure of the catalytic domain of unliganded PDE5

Summary for 2H40

Entry DOI	10.2210/pdb2h40/pdb
Related	2H42 2H44
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	pde5, unliganded, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	37878.25
Authors	Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. (deposition date: 2006-05-23, release date: 2006-06-06, Last modification date: 2023-08-30)
Primary citation	Wang, H.,Liu, Y.,Huai, Q.,Cai, J.,Zoraghi, R.,Francis, S.H.,Corbin, J.D.,Robinson, H.,Xin, Z.,Lin, G.,Ke, H. Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development J.Biol.Chem., 281:21469-21479, 2006 Cited by PubMed: 16735511 DOI: 10.1074/jbc.M512527200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation